ArticleCancer epidemiology2012
Family history of cancer and non-malignant diseases and risk of childhood acute lymphoblastic leukemia: a Children's Oncology Group Study.
Article in Cancer epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Maternal Thyroid Diseases, Medication Use and Childhood Cancer Risks in Offspring: A Population-Based Cohort Study in Denmark.International journal of cancer · 2026Article
- Epidemiological Profile of Pediatric Patients with Acute Lymphoblastic Leukemia Admitted to Four Hospitals in Curitiba, Southern Brazil.Medical sciences (Basel, Switzerland) · 2026Article
- Application of an obstetric comorbidity index to predict childhood cancer risk: a population based case-control study in Denmark.British journal of cancer · 2025Article
- Maternal autoimmune disease and offspring risk of haematological malignancies: a case-control study.EClinicalMedicine · 2024Article
- Maternal autoimmune disease and its association with childhood cancer: A population-based case-control study in Denmark.EJC paediatric oncology · 2024Article
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- Maternal autoimmune disease is not associated with cancer in the offspring.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations.Scientific reports · 2021Article
- The study of association between reduced folate carrier 1 (BioImpacts : BI · 2017Article
- Discussing and managing hematologic germ line variants.Hematology. American Society of Hematology. Education Program · 2016Review
- Association Between RFC1 G80A Polymorphism and Acute Lymphoblastic Leukemia: a Review and Meta-Analysis of 10 Studies.Iranian journal of pediatric hematology and oncology · 2016Review
- Childhood acute lymphoblastic leukemia and indicators of early immune stimulation: a Childhood Leukemia International Consortium study.American journal of epidemiology · 2015Article
- Familial leukemias.Current treatment options in oncology · 2015Review
- The Childhood Leukemia International Consortium.Cancer epidemiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundStudies of family history of cancer and non-malignant diseases in childhood acute lymphoblastic leukemia (ALL) show inconsistent findings. Most studies show no increased risk with family history of cancer. Non-malignant diseases such as allergic diseases, autoimmune diseases, birth defects and thyroid diseases have been reported to be associated with ALL.
methodsWe conducted a case-control study of family history of cancer and selected non-malignant conditions (allergic diseases, autoimmune diseases, birth defects, and thyroid diseases). ALL cases were obtained from Children's Cancer Group institutions from January 1989 to June 1993. Controls were recruited via random digit dialing. Family history for first degree relatives and grandparents of ALL cases and controls was collected by structured telephone questionnaires. Conditional logistical regression was used to calculate odds ratios adjusting for potential confounders.
resultsWe found a borderline association of ALL and having a family member with a history of cancer in cases (n=1842) compared to controls (n=1986) (OR=0.98, 95%CI=0.93, 1.00) and an inverse association for esophageal cancer based on small numbers. Family history of food and drug allergies demonstrated a modestly reduced risk (OR=0.83, 95%CI=0.73, 0.95) as did family history of rheumatoid arthritis (OR=0.79, 95%CI=0.65, 0.96). There were no associations with family history of any autoimmune diseases, immunodeficiencies, birth defects, thyroid diseases and risk of childhood ALL.
conclusionsThese results show no association of overall family history of cancer with childhood ALL, while providing additional evidence for an inverse association with family history of allergic disease. Two potentially new associations of ALL with family history of esophageal cancer and rheumatoid arthritis require confirmation in other studies and validation with medical records.
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