ArticleThe Journal of allergy and clinical immunology2012
Anaphylaxis in a New York City pediatric emergency department: triggers, treatments, and outcomes.
Article in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 210 citations in OpenAlex.
- Risk factors for severe reactions in food allergy: Rapid evidence review with meta-analysis.Allergy · 2022Pooled it
- Global patterns in anaphylaxis due to specific foods: A systematic review.The Journal of allergy and clinical immunology · 2021Pooled it
- Use of multiple epinephrine doses in anaphylaxis: A systematic review and meta-analysis.The Journal of allergy and clinical immunology · 2021Pooled it
- Epinephrine treatment of food-induced and other cause anaphylaxis in United States and Canadian Emergency Departments: a systematic review and meta-analysis.Expert review of clinical immunologyPooled it
- Geospatial and insurance barriers to allergist access across the Midwest.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- RECOVER Guidelines: First Aid. Evidence, Treatment Recommendations, Knowledge Gap Analysis, and Clinical Guidelines for Acute Allergy and Anaphylaxis in Dogs and Cats.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2026Article
- Introduction from the editors.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025Article
- Immunoglobulin E (IgE)-mediated food allergy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Review
- A metagenomic next-generation sequencing (mNGS)-based analysis of bronchoalveolar lavage samples in patients with an acute exacerbation of chronic obstructive pulmonary disease.Journal of molecular histology · 2024Article
- Article
- Viral Vector Based Immunotherapy for Peanut Allergy.Viruses · 2024Review
- Addressing Health Equity in Food Allergy.The journal of allergy and clinical immunology. In practice · 2024Article
- Who Needs Epinephrine? Anaphylaxis, Autoinjectors, and Parachutes.The journal of allergy and clinical immunology. In practice · 2023Review
- Latin American anaphylaxis registry.The World Allergy Organization journal · 2023Article
- Evaluation of the triggers and the treatment models of anaphylaxis in pediatric patients.Northern clinics of Istanbul · 2023Article
- Triage Grading and Correct Diagnosis Are Critical for the Emergency Treatment of Anaphylaxis.Children (Basel, Switzerland) · 2022Article
- Incidence, triggering factors, symptoms, and treatment of anaphylaxis in a pediatric hospital.The World Allergy Organization journal · 2022Article
- Emergency department childhood anaphylaxis presentations in regional/remote Australia.Journal of paediatrics and child health · 2022Article
- Emergency treatment of anaphylaxis: concise clinical guidance.Clinical medicine (London, England) · 2022Article
- Drug-Related Hypersensitivity Reactions Leading to Emergency Department: Original Data and Systematic Review.Journal of clinical medicine · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAnaphylaxis incidence is increasing.
objectiveWe sought to characterize anaphylaxis in children in an urban pediatric emergency department (PED).
methodsWe performed a review of PED records for anaphylactic reactions over 5 years.
resultsWe identified 213 anaphylactic reactions in 192 children (97 male patients): 6 were infants, 20 had multiple reactions, and the median age was 8 years (age range, 4 months to 18 years). Sixty-two reactions were coded as anaphylaxis; 151 additional reactions met the second symposium anaphylaxis criteria. There was no increase in incidence over 5 years. The triggers included the following: foods, 71%; unknown, 15%; drugs, 9%; and "other," 5%. Food was more likely to be a trigger in multiple PED visits (P = .03). Epinephrine was administered in 169 (79%) reactions; in 58 (27%) reactions epinephrine was administered before arrival in the PED. Patients with Medicaid were less likely to receive epinephrine before arrival in the PED (P < .001). Twenty-eight (14.6%) patients were hospitalized, 9 in the intensive care unit. For 13 (6%) of the reactions, 2 doses of epinephrine were administered; 69% of the patients treated with 2 doses of epinephrine were hospitalized compared with 12% of the patients treated with a single dose (P < .001). Administration of both epinephrine doses before arrival to the PED was associated with a lower rate of hospitalization compared with epinephrine administration in the PED (P = .05).
conclusionsFood is the main anaphylaxis trigger in the urban PED, although the International Classification of Diseases-ninth revision code for anaphylaxis is underused. Treatment with 2 doses of epinephrine is associated with a higher risk of hospitalization; epinephrine treatment before arrival to the PED is associated with a decreased risk. Children with Medicaid are less likely to receive epinephrine before arrival in the PED.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.