ArticleVirology2011
The mechanism of DNA ejection in the Bacillus anthracis spore-binding phage 8a revealed by cryo-electron tomography.
Article in Virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Phage-specific immunity impairs efficacy of bacteriophage targeting Vancomycin Resistant Enterococcus in a murine model.Nature communications · 2024Article
- Bacteriophage Receptor Recognition and Nucleic Acid Transfer.Sub-cellular biochemistry · 2024Review
- Cryo-electron microscopy in the study of virus entry and infection.Frontiers in molecular biosciences · 2024Review
- Isolation, Characterization andInfection & chemotherapy · 2022Article
- Phages Bind to Vegetative and Spore Forms ofFrontiers in microbiology · 2021Article
- Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end.The EMBO journal · 2018Article
- Predicting genome terminus sequences of Bacillus cereus-group bacteriophage using next generation sequencing data.BMC genomics · 2017Article
- A new view into prokaryotic cell biology from electron cryotomography.Nature reviews. Microbiology · 2016Review
- Possible use of bacteriophages active against Bacillus anthracis and other B. cereus group members in the face of a bioterrorism threat.BioMed research international · 2014Review
- Cryo-electron tomography of bacterial viruses.Virology · 2013Review
- Cryo-electron microscopy--a primer for the non-microscopist.The FEBS journal · 2013Review
- Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Limiting factors in single particle cryo electron tomography.Computational and structural biotechnology journal · 2012Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The structure of the Bacillus anthracis spore-binding phage 8a was determined by cryo-electron tomography. The phage capsid forms a T=16 icosahedron attached to a contractile tail via a head-tail connector protein. The tail consists of a six-start helical sheath surrounding a central tail tube, and a structurally novel baseplate at the distal end of the tail that recognizes and attaches to host cells. The parameters of the icosahedral capsid lattice and the helical tail sheath suggest protein folds for the capsid and tail-sheath proteins, respectively, and indicate evolutionary relationships to other dsDNA viruses. Analysis of 2518 intact phage particles show four distinct conformations that likely correspond to four sequential states of the DNA ejection process during infection. Comparison of the four observed conformations suggests a mechanism for DNA ejection, including the molecular basis underlying coordination of tail sheath contraction and genome release from the capsid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.