ArticleCritical care (London, England)2011
Is plasma calcium concentration implicated in the development of critical illness polyneuropathy and myopathy?
Article in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Aminoglycoside use and intensive care unit-acquired weakness: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Corticosteroid use and intensive care unit-acquired weakness: a systematic review and meta-analysis.Critical care (London, England) · 2018Pooled it
- Risk Factors and Prediction Model for ICU-Acquired Weakness in Severe Acute Pancreatitis: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Supplementation of calcium, magnesium, phosphate, and potassium in critically ill patients: A multicenter cohort study.PloS one · 2026Article
- Parenteral calcium administration and outcomes in critically ill patients with hypocalcemia: A retrospective cohort study.Journal of intensive medicine · 2025Article
- Risk factors for ICU-acquired weakness in sepsis patients: A retrospective study of 264 patients.Heliyon · 2024Article
- Development and validation of an intensive care unit acquired weakness prediction model: A cohort study.Frontiers in medicine · 2023Article
- Photostable and Proteolysis-Resistant Förster Resonance Energy Transfer-Based Calcium Biosensor.Analytical chemistry · 2020Article
- Early Prediction of Intensive Care Unit-Acquired Weakness: A Multicenter External Validation Study.Journal of intensive care medicine · 2020Observational
- Association of Initial Serum Total Calcium Concentration with Mortality in Critical Illness.BioMed research international · 2018Article
- Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features.BMC neurology · 2016Article
- The effect of hemodialysis on balance measurements and risk of fall.International urology and nephrology · 2016Article
- The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.Physiological reviews · 2015Review
- Calcium supplementation improves clinical outcome in intensive care unit patients: a propensity score matched analysis of a large clinical database MIMIC-II.SpringerPlus · 2015Article
- Critical illness polyneuropathy and myopathy: a systematic review.Neural regeneration research · 2014Article
- Early prediction of intensive care unit-acquired weakness using easily available parameters: a prospective observational study.PloS one · 2014Observational
- Dose and type of crystalloid fluid therapy in adult hospitalized patients.Perioperative medicine (London, England) · 2013Article
- Year in review 2011: Critical Care--Neurocritical care.Critical care (London, England) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis prospective study investigated whether plasma ionized calcium concentration abnormalities and other electrolyte disturbances represent risk factors for the development of critical illness polyneuromyopathy (CIPNM) in ICU patients.
methodsOne hundred and ninety consecutive adult critically ill patients with prolonged ICU stay (longer than 7 days) were prospectively evaluated. Patients with acute weakness and/or weaning difficulties were subjected to extensive electrophysiological measurements in order to establish the diagnosis of CIPNM. All recognized and/or possible risk factors for development of CIPNM were recorded.
resultsThe diagnosis of CIPNM was confirmed in 40 patients (21.05%). By applying a logistic regression model, hypocalcemia (P = 0.02), hypercalcemia (P = 0.01) and septic shock (P = 0.04) were independently associated with the development of CIPNM in critically ill patients.
conclusionsWe found that septic shock and abnormal fluctuations of plasma Ca²⁺ concentration represent significant risk factors for the development of CIPNM in critically ill patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.