ReviewClinical and experimental rheumatology
Glucocorticoid receptor: implications for rheumatic diseases.
Review in Clinical and experimental rheumatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Individual Cortisol Production in Active Rheumatoid Arthritis Associates with Treatment Responses: A Pilot, Two-Year Study.Mediterranean journal of rheumatology · 2025Article
- Dexamethasone for Severe COVID-19: How Does It Work at Cellular and Molecular Levels?International journal of molecular sciences · 2021Review
- Metabolic rivalry: circadian homeostasis and tumorigenesis.Nature reviews. Cancer · 2020Review
- Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone.International journal of molecular sciences · 2017Article
- Stress-Related and Circadian Secretion and Target Tissue Actions of Glucocorticoids: Impact on Health.Frontiers in endocrinology · 2017Review
- Vitamin D interferes with glucocorticoid responsiveness in human peripheral blood mononuclear target cells.Cellular and molecular life sciences : CMLS · 2016Article
- Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments.Oncoscience · 2016Review
- Cross-talk between HPA-axis-increased glucocorticoids and mitochondrial stress determines immune responses and clinical manifestations of patients with sepsis.Redox report : communications in free radical research · 2015Review
- Circadian endocrine rhythms: the hypothalamic-pituitary-adrenal axis and its actions.Annals of the New York Academy of Sciences · 2014Review
- Circulating cortisol-associated signature of glucocorticoid-related gene expression in subcutaneous fat of obese subjects.Obesity (Silver Spring, Md.) · 2013Article
- Circadian rhythms of glucocorticoid hormone actions in target tissues: potential clinical implications.Science signaling · 2012Article
- Mid-gestational gene expression profile in placenta and link to pregnancy complications.PloS one · 2012Article
- Chronopharmacology of glucocorticoids.Advanced drug delivery reviewsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The glucocorticoid receptor (GR), a member of the nuclear receptor superfamily, mediates most of the known biologic effects of glucocorticoids. The human GR gene consists of 9 exons and expresses 2 alternative splicing isoforms, the GRα and GRβ. GRα is the classic receptor that binds to glucocorticoids and mediates most of the known actions of glucocorticoids, while GRβ does not bind to these hormones and exerts a dominant negative effect upon the GRα-induced transcriptional activity. Each of the two GR splice isoforms has 8 translational variants with specific transcriptional activity and tissue distribution. GRα consists of three subdomains, translocates from the cytoplasm into the nucleus upon binding to glucocorticoids, and regulates the transcriptional activity of numerous glucocorticoid-responsive genes either by binding to its cognate DNA sequences or by interacting with other transcription factors. In addition to these genomic actions, the GR also exerts rapid, non-genomic effects, which are possibly mediated by membrane-localised receptors or by translocation into the mitochondria. All these actions of the GR appear to play an important role in the regulation of the immune system. Specifically, the splicing variant GRβ may be involved in the pathogenesis of rheumatic diseases, while the circadian regulation of the GR activity via acetylation by the Clock transcription factor may have therapeutic implications for the preferential timing of glucocorticoid administration in autoimmune inflammatory disorders.
Indexed as
Identifiers
22018181PMC3630375W71521485What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.