ArticleMolecular cell2011
Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding.
Article in Molecular cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Cbf11 and Mga2 function together to activate transcription of lipid metabolism genes and promote mitotic fidelity in fission yeast.PLoS genetics · 2024Article
- A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis.Nature communications · 2023Article
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- COmBio · 2019Article
- Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development.Seminars in cell & developmental biology · 2018Review
- The Zap1 transcriptional activator negatively regulates translation of the RTC4 mRNA through the use of alternative 5' transcript leaders.Molecular microbiology · 2017Article
- Article
- Article
- Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis.The Journal of biological chemistry · 2014Article
- Zinc finger transcription factors displaced SREBP proteins as the major Sterol regulators during Saccharomycotina evolution.PLoS genetics · 2014Article
- Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.The Journal of biological chemistry · 2013Article
- Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation.Molecular biology of the cell · 2012Article
- Regulation of lipid metabolism: a tale of two yeasts.Current opinion in cell biology · 2012Review
- Identifying a static nonlinear structure in a biological system using noisy, sparse data.Journal of theoretical biology · 2012Article
- Sterols for Oxygen: The Metabolic Burden of Microbial SREBP.Molecular cell · 2011Article
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4 authors at 2 institutions in 1 country.
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Abstract
Regulation of gene expression plays an integral role in adaptation of cells to hypoxic stress. In mammals, prolyl hydroxylases control levels of the central transcription factor hypoxia inducible factor (HIF) through regulation of HIFα subunit stability. Here, we report that the hydroxylase Ofd1 regulates the Sre1 hypoxic transcription factor in fission yeast by controlling DNA binding. Prolyl hydroxylases require oxygen as a substrate, and the activity of Ofd1 regulates Sre1-dependent transcription. In the presence of oxygen, Ofd1 binds the Sre1 N-terminal transcription factor domain (Sre1N) and inhibits Sre1-dependent transcription by blocking DNA binding. In the absence of oxygen, the inhibitor Nro1 binds Ofd1, thereby releasing Sre1N and leading to activation of genes required for hypoxic growth. In contrast to the HIF system, where proline hydroxylation is essential for regulation, Ofd1 inhibition of Sre1N does not require hydroxylation and, thus, defines a new mechanism for hypoxic gene regulation.
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