Evidence map›Paper›PMID 22017866›Full record

ArticleMolecular cell2011

Sterols for Oxygen: The Metabolic Burden of Microbial SREBP.

Timothy F Osborne

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Timothy F OsborneMetabolic Signaling and Disease Program, Obesity and Diabetes Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA. tosborne@sanfordburnham.org
Sanford Burnham Prebys Medical Discovery Institute · US

Funding

Sterol Regulatory Element Binding Proteins in Regulation of Lipid MetabolismR01HL048044 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI OSBORNE, TIMOTHY F · 1993 to 2017
$7.3M
NHLBI NIH HHS R01 HL048044
6 · The paper itself

Abstract

In this issue of Molecular Cell, Lee et al. (2011) report a novel mechanism for oxygen-sensing in S. pombe, whereby the 2-OG-Fe(II) dioxygenase Ofd protein regulates both the DNA-binding activity and the degradation of the hypoxia regulated transcription factor, Sre1p.

Identifiers

PMID22017866
PMCPMC3226767
OpenAlexW2021250897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.