Clinical evidence for neuroprotection in glaucoma.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Neuroprotection for treatment of glaucoma in adults.The Cochrane database of systematic reviews · 2017
   Pooled it
2. Neuroprotection for treatment of glaucoma in adults.The Cochrane database of systematic reviews · 2013
   Pooled it
3. Neuroprotective Activity of Rasayana Formulation and Effect of Shigru Pallava Eye Drops on Intraocular Pressure as an Add-on Therapy Compared to the Standard of Care in Primary Open-Angle Glaucoma: Protocol for an Exploratory, Open-label, Two-arm Randomized Controlled Trial.F1000Research · 2025
   Article
4. Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future.Frontiers in neurology · 2022
   Review
5. An Innovative In Vitro Open-Angle Glaucoma Model (IVOM) Shows Changes Induced by Increased Ocular Pressure and Oxidative Stress.International journal of molecular sciences · 2021
   Article
6. Activation of adenosine ACell death & disease · 2020
   Article
7. High hydrostatic pressure induces apoptosis of retinal ganglion cells via regulation of the NGF signalling pathway.Molecular medicine reports · 2019
   Article
8. Microglia in Retinal Degeneration.Frontiers in immunology · 2019
   Review
9. European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition - Chapter 3: Treatment principles and options Supported by the EGS Foundation: Part 1: Foreword; Introduction; Glossary; Chapter 3 Treatment principles and options.The British journal of ophthalmology · 2017
   Article
10. Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma.Scientific reports · 2016
    Article
11. Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure.Journal of neuroinflammation · 2015
    Article
12. Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases.Mediators of inflammation · 2015
    Review
13. Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases.Mediators of inflammation · 2014
    Review
14. 17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma.Molecular pharmaceutics · 2013
    Article
15. Ocular disposition of the hemiglutarate ester prodrug of ∆⁹-Tetrahydrocannabinol from various ophthalmic formulations.Pharmaceutical research · 2013
    Article
16. New trends in glaucoma risk, diagnosis & management.The Indian journal of medical research · 2013
    Review
17. Solving the lost in translation problem: improving the effectiveness of translational research.Current opinion in pharmacology · 2013
    Review

Corrections and comments

• Comment on
  A randomized trial of brimonidine versus timolol in preserving visual function: results from the Low-Pressure Glaucoma Treatment Study.2011

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as