ArticleAnalytical chemistry2011
Stretched tissue mounting for MALDI mass spectrometry imaging.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Sequential MALDI and Nano-DESI MS Imaging of Lipids and Proteins on Stretched Tissue Samples.Analytical chemistry · 2026Article
- Dry Deposition Strategies for MALDI-MS Imaging: Principles, Advances and Emerging Applications.Analytical science advances · 2026Review
- Gel-assisted mass spectrometry imaging enables sub-micrometer spatial lipidomics.Nature communications · 2024Article
- Bringing SEM and MSI Closer Than Ever Before: VisualizingJournal of fungi (Basel, Switzerland) · 2020Article
- Correlative microscopy of freeze-dried cells and studies on intracellular calcium stores with imaging secondary ion mass spectrometry (SIMS).Journal of analytical atomic spectrometry · 2019Article
- Time-of-flight secondary ion mass spectrometry based molecular histology of human spinal cord tissue and motor neurons.Analytical chemistry · 2013Article
- Mass spectrometry imaging for biomedical applications.Analytical and bioanalytical chemistry · 2013Article
- Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS.Journal of mass spectrometry : JMS · 2012Article
- Mass spectrometry imaging and profiling of single cells.Journal of proteomics · 2012Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) combines information-rich chemical detection with spatial localization of analytes. For a given instrumental platform and analyte class, the data acquired can represent a compromise between analyte extraction and spatial information. Here, we introduce an improvement to the spatial resolution achievable with MALDI MSI conducted with standard mass spectrometric systems that also reduces analyte migration during matrix application. Tissue is placed directly on a stretchable membrane that, when stretched, fragments the tissue into micrometer-sized pieces. Scanning electron microscopy analysis shows that this process produces fairly homogeneous distributions of small tissue fragments separated and surrounded by areas of hydrophobic membrane surface. MALDI matrix is then applied by either a robotic microspotter or an artist's airbrush. Rat spinal cord samples imaged with an instrumental resolution of 50-250 μm demonstrate lipid distributions with a 5-fold high spatial resolution (a 25-fold increase in pixel density) after stretching compared to tissues that were not stretched.
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Registered trials
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