Evidence map›Paper›PMID 22017425›Full record

ArticleCancer science2012

High CpG island methylator phenotype is associated with lymph node metastasis and prognosis in gastric cancer.

Hua-Yun Chen, Bao-He Zhu, Chang-Hua Zhang, Dong-Jie Yang, Jian-Jun Peng, Jian-Hui Chen, Fa-Keng Liu, Yu-Long He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hua-Yun ChenDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Bao-He Zhu
Chang-Hua Zhang
Dong-Jie Yang
Jian-Jun Peng
Jian-Hui Chen
Fa-Keng Liu
Yu-Long He

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have found that the promoter CpG island is frequently methylated in gastric cancer. The CpG island methylator phenotype (CIMP) defines concordant methylation of multiple promoter CpG island loci in a subset of gastric cancer. However, the relationship between CIMP and lymph node metastasis in gastric cancer is unknown. Our study aimed to characterize the role of CIMP in lymph node metastasis. Clinical specimens from 120 patients were analyzed and PCR was used to detect the methylation status of five genes (ALX4, TMEFF2, CHCHD10, IGFBP3, and NPR1). We measured the level of mRNA for the five genes by real-time RT-PCR. Microsatellite instability and Helicobacter pylori infection status were assayed by capillary electrophoresis and real-time PCR, respectively. DNA methylation in the five genes was correlated with low expression of the respective mRNA. With CIMP as the dependent variable, CIMP-high gastric cancer tended to show more distant lymph node metastasis, higher pathologic tumor classification, more pathologic metastasis, and higher pathologic TNM status. Microsatellite instability and H. pylori status were not significant predictors of prognosis. CIMP-high gastric cancer showed significantly worse survival compared with that of CIMP-low/CIMP-negative gastric cancer (P < 0.001). Our results show that there is an association between CIMP status and lymph node metastasis in gastric cancer and CIMP-high was an independent prognostic factor.

Indexed as

DNA MethylationGene Expression Regulation, NeoplasticGenes, Tumor SuppressorAdultAgedAged, 80 and overCpG IslandsDNA-Binding ProteinsFemaleHelicobacter InfectionsHelicobacter pyloriHumansInsulin-Like Growth Factor Binding Protein 3Lymphatic MetastasisMaleMembrane ProteinsALX4 protein, humanatrial natriuretic factor receptor ACHCHD10 protein, humanDNA-Binding ProteinsIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Membrane ProteinsMitochondrial ProteinsNeoplasm ProteinsReceptors, Atrial Natriuretic FactorRNA, NeoplasmTMEFF2 protein, humanTranscription Factors

Identifiers

PMID22017425
PMCPMC11164149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.