Trial reportJournal of endourology2011
Oral antibiotic treatment of Helicobacter pylori leads to persistently reduced intestinal colonization rates with Oxalobacter formigenes.
Trial report in Journal of endourology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 67 citations in OpenAlex.
- The effects of antibiotics use during early life and genetic risk on urolithiasis incidence: a large-scale UK biobank cohort study.World journal of urology · 2025Article
- Complex system modeling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria.eLife · 2025Article
- InducingKidney international reports · 2025Article
- Helicobacter Pylori Infection as an Independent Risk Factor for Kidney Stone Formation in China: A Cross-Sectional Study.Infection and drug resistance · 2025Article
- Increased Rates of Supplement-Associated Oxalate Nephropathy During COVID-19 Pandemic.Kidney international reports · 2022Article
- Review
- Forty Years of Oxalobacter formigenes, a Gutsy Oxalate-Degrading Specialist.Applied and environmental microbiology · 2021Review
- Effect of antibiotic treatment on Oxalobacter formigenes colonization of the gut microbiome and urinary oxalate excretion.Scientific reports · 2021Article
- Kidney stone formation and the gut microbiome are altered by antibiotics in genetic hypercalciuric stone-forming rats.Urolithiasis · 2021Article
- Article
- Dietary Oxalate Intake and Kidney Outcomes.Nutrients · 2020Review
- The relationship between calcium oxalate lithiasis and chronic proinflammatory intestinal dysbiosis pattern: a prospective study.Urolithiasis · 2020Article
- Development of a Humanized Murine Model for the Study of Oxalobacter formigenes Intestinal Colonization.The Journal of infectious diseases · 2019Article
- The use of antibiotics and risk of kidney stones.Current opinion in nephrology and hypertension · 2019Review
- Inhibition of urinary stone disease by a multi-species bacterial network ensures healthy oxalate homeostasis.Kidney international · 2019Article
- Understanding the Link Between Gut Microbiome and Urinary Stone Disease.Current urology reports · 2019Review
- Comparative prevalence of Oxalobacter formigenes in three human populations.Scientific reports · 2019Article
- Oral Antibiotic Exposure and Kidney Stone Disease.Journal of the American Society of Nephrology : JASN · 2018Article
- Updates in the Metabolic Management of Calcium Stones.Current urology reports · 2018Review
- Gut microbiota and oxalate homeostasis.Annals of translational medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeOxalobacter formigenes (OF) may play a protective role in preventing calcium oxalate stones. This is the first prospective study to evaluate the effect of antibiotics on OF colonization. Intestinal colonization by OF is associated with reduced urinary oxalate excretion. Exposure to antibiotics may be an important factor determining rates of colonization. MATERIALS AND
methodsThe effect of antibiotics on OF colonization was compared in two groups: A group receiving antibiotics for gastric infection with Helicobacter pylori (HP) and a group without HP whose members were not receiving antibiotics. OF colonization in stool was detected by oxalate degradation at baseline and after 1 and 6 months.
resultsThe prevalence at baseline of intestinal colonization with OF was 43.1% among all patients screened. Among the 12 patients who were positive for OF who did not receive antibiotics, 11 (92%) had OF on stool tests at 1 month and 6 months. Of the 19 participants who were positive for OF and who received antibiotics for HP, only 7 (36.8%) continued to be colonized by OF on follow-up stool testing at 1 and 6 months (P=0.003 by Fisher exact test). Amoxicillin and clarithromycin caused 62.5% of subjects to become negative for OF at 1 month; 56.2% remained negative for OF at 6 months.
conclusionsAntibiotics for HP infection effectively reduced colonization with OF, an effect present at 1 and 6 months after treatment. The lasting elimination of OF could be associated with hyperoxaluria and be a factor in recurrent kidney stone disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.