ArticleMobile genetic elements2011
An epi [c] genetic battle: LINE-1 retrotransposons and intragenomic conflict in humans.
Article in Mobile genetic elements, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The Sophisticated Transcriptional Response Governed by Transposable Elements in Human Health and Disease.International journal of molecular sciences · 2020Review
- The impact of transposable element activity on therapeutically relevant human stem cells.Mobile DNA · 2019Review
- Transposable Elements Activity is Positively Related to Rate of Speciation in Mammals.Journal of molecular evolution · 2018Article
- LINE-1 retrotransposons in healthy and diseased human brain.Developmental neurobiology · 2018Review
- LINE-1 hypermethylation in peripheral blood of cutaneous melanoma patients is associated with metastasis.Melanoma research · 2015Article
- Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain.Translational psychiatry · 2014Article
- Control of mammalian retrotransposons by cellular RNA processing activities.Mobile genetic elements · 2014Article
- Evolution of HLA-DRB genes.Molecular biology and evolution · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
The ongoing activity of the human retrotransposon Long Interspersed Element 1 (LINE-1 or L1) continues to impact the human genome in various ways. Throughout evolution, mammalian and primate genomes have been under selection to generate strategies to reduce the activity of selfish DNA like L1. Similarly, selfish DNA has evolved to elude these containment systems. This intragenomic conflict has left many inactive versions of LINEs and other Transposable Elements (TEs) littering the human genome, which together account for roughly half of our DNA. Here, we survey the distinct mechanisms operating in the human genome that seem to reduce the mobility of L1s. In addition, we discuss recent findings that strongly suggest epigenetic mechanisms specifically regulate L1 activity in pluripotent human cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.