ArticleAmerican journal of cancer research2011
Menin represses tumorigenesis via repressing cell proliferation.
Article in American journal of cancer research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- An integrated analysis of MEN1 reveals its associations with clinical outcomes, cellular pathways, and the immune microenvironment.World journal of surgical oncology · 2026Article
- JUNB and JUND in Urological Cancers: A Literature Review.Current issues in molecular biology · 2025Review
- Menin in Cancer.Genes · 2024Review
- Menin Reduces Parvalbumin Expression and is Required for the Anti-Depressant Function of Ketamine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Molecular and Clinical Spectrum of Primary Hyperparathyroidism.Endocrine reviews · 2023Article
- Senescent CD8Cancer science · 2023Article
- Menin represses the proliferation of gastric cancer cells by interacting with IQGAP1.Biomedical reports · 2023Article
- The role of menin in bone pathology.Endocrine connections · 2022Review
- A Novel Isogenic Human Cell-Based System for MEN1 Syndrome Generated by CRISPR/Cas9 Genome Editing.International journal of molecular sciences · 2021Article
- Circulating microRNA-762 upregulation in colorectal cancer may be accompanied by Wnt-1/β-catenin signaling.Cancer biomarkers : section A of Disease markers · 2021Article
- Novel Mutations in Serbian MEN1 Patients: Genotype-phenotype Correlation.Journal of medical biochemistry · 2019Article
- Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27The Journal of pathology · 2018Article
- The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation.Nature communications · 2018Article
- Epigenetic regulation in the tumorigenesis of MEN1-associated endocrine cell types.Journal of molecular endocrinology · 2018Review
- Multiple Endocrine Neoplasia Syndromes from Genetic and Epigenetic Perspectives.Biomarker insights · 2018Review
- Menin Modulates Mammary Epithelial Cell Numbers in Bovine Mammary Glands Through Cyclin D1.Journal of mammary gland biology and neoplasia · 2017Article
- miR-762 can negatively regulate menin in ovarian cancer.OncoTargets and therapy · 2017Article
- The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis.Nature communications · 2014Article
- Altered MENIN expression disrupts the MAFA differentiation pathway in insulinoma.Endocrine-related cancer · 2013Article
- Current understanding of the molecular biology of pancreatic neuroendocrine tumors.Journal of the National Cancer Institute · 2013Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Multiple endocrine neoplasia type 1 (MEN1) results from mutations in the tumor suppressor gene, MEN1, which encodes nuclear protein menin. Menin is important for suppressing tumorigenesis in various endocrine and certain non-endocrine tissues. Although menin suppresses MEN1 through a variety of mechanisms including regulating apoptosis and DNA repair, the role of menin in regulating cell proliferation is one of the best-studied functions. Here, we focus on reviewing various mechanisms underlying menin-mediated inhibition of cell proliferation. Menin inhibits cell proliferation to repress MEN1 through multiple mechanisms. 1) Menin interacts with various histonemodifying enzymes, such as MLL, EZH2 and HDACs, to affect gene transcription, leading to repression of cell proliferation. 2) Menin also interacts with various transcription factors, such as JunD, NF-κB, PPARγ and VDR, to induce or suppress gene transcription. As these various transcription factors are known to regulate cell proliferation, their interaction with menin may be relevant to menin's role in inhibiting cell proliferation. 3) Menin inhibits cell proliferation via TGF-β signaling and Wnt/β-catenin signaling pathways. 4) Menin represses certain pro-proliferative factors involved in endocrine tumors such as IGFBP-2, IGF2 and PTHrP to repress cell proliferation. 5) Menin affects cell cycle progression to inhibit cell proliferation. This review is helpful in our understanding of the comprehensive mechanisms whereby menin represses MEN1 through inhibiting cell proliferation.
Indexed as
Identifiers
22016823PMC3195934W80825425What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.