ArticlePloS one2011
Insights into the molecular mechanisms of the anti-atherogenic actions of flavonoids in normal and obese mice.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Effects of Fermented Compound Chinese Herbal Feed on Gut Microbiota, Immune Response, and Disease Resistance in Chinese Soft-Shelled Turtle (Animals : an open access journal from MDPI · 2026Article
- Leveraging genetic resources and genomic prediction to enhance flavonol content in cranberry fruit.The plant genome · 2025Article
- Effects of Extended Treatment withBiology · 2024Article
- A combination ofFood & nutrition research · 2024Article
- Skeletal Muscle Uncoupling Proteins in Mice Models of Obesity.Metabolites · 2022Review
- Contrasting a reference cranberry genome to a crop wild relative provides insights into adaptation, domestication, and breeding.PloS one · 2022Article
- Effect of thermal processing methods on flavonoid and isoflavone content of decorticated and whole pulses.Journal of food science and technology · 2021Article
- Cranberry Polyphenols: Natural Weapons against Dental Caries.Dentistry journal · 2019Review
- A Boost in Mitochondrial Activity Underpins the Cholesterol-Lowering Effect of Annurca Apple Polyphenols on Hepatic Cells.Nutrients · 2019Article
- Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Massive phenotyping of multiple cranberry populations reveals novel QTLs for fruit anthocyanin content and other important chemical traits.Molecular genetics and genomics : MGG · 2018Article
- Article
- Establishment of combined analytical method to extract the genes of interest from transcriptome data.Biochemistry and biophysics reports · 2016Article
- Article
- Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.Pharmacological reviews · 2014Review
- The American cranberry: first insights into the whole genome of a species adapted to bog habitat.BMC plant biology · 2014Article
- Cranberries and their bioactive constituents in human health.Advances in nutrition (Bethesda, Md.) · 2013Review
- The first genetic map of the American cranberry: exploration of synteny conservation and quantitative trait loci.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Antiviral activity of baicalein and quercetin against the Japanese encephalitis virus.International journal of molecular sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a major and independent risk factor for cardiovascular disease and it is strongly associated with the development of dyslipidemia, insulin resistance and type 2 diabetes. Flavonoids, a diverse group of polyphenol compounds of plant origin widely distributed in human diet, have been reported to have numerous health benefits, although the mechanisms underlying these effects have remained obscure. We analyzed the effects of chronic dietary supplementation with flavonoids extracted from cranberry (FLS) in normal and obese C57/BL6 mice compared to mice maintained on the same diets lacking FLS. Obese mice supplemented with flavonoids showed an amelioration of insulin resistance and plasma lipid profile, and a reduction of visceral fat mass. We provide evidence that the adiponectin-AMPK pathway is the main mediator of the improvement of these metabolic disorders. In contrast, the reduced plasma atherogenic cholesterol observed in normal mice under FLS seems to be due to a downregulation of the hepatic cholesterol synthesis pathway. Overall, we demonstrate for the first time that the molecular mechanisms underlying the beneficial effects of flavonoids are determined by the metabolic state.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.