ArticleFrontiers in molecular neuroscience2011
Pluripotent stem cells for the study of CNS development.
Article in Frontiers in molecular neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling.Signal transduction and targeted therapy · 2026Article
- Current Applications of Human Pluripotent Stem Cells in Neuroscience Research and Cell Transplantation Therapy for Neurological Disorders.Stem cell reviews and reports · 2025Review
- Long-term calcium imaging reveals functional development in hiPSC-derived cultures comparable to human but not rat primary cultures.Stem cell reports · 2023Article
- Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation.BMC molecular and cell biology · 2021Article
- Review
- Neuronal Replacement in Stem Cell Therapy for Stroke: Filling the Gap.Frontiers in cell and developmental biology · 2021Review
- Ventral Telencephalic Patterning Protocols for Induced Pluripotent Stem Cells.Frontiers in cell and developmental biology · 2021Article
- Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders.Frontiers in cellular neuroscience · 2020Review
- Develop a 3D neurological disease model of human cortical glutamatergic neurons using micropillar-based scaffolds.Acta pharmaceutica Sinica. B · 2019Article
- Organs to Cells and Cells to Organoids: The Evolution ofFrontiers in cellular neuroscience · 2019Review
- Induced Pluripotent Stem Cells: A Powerful Neurodegenerative Disease Modeling Tool for Mechanism Study and Drug Discovery.Cell transplantation · 2018Article
- Generation of defined neural populations from pluripotent stem cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Measles Virus Persistent Infection of Human Induced Pluripotent Stem Cells.Cellular reprogramming · 2018Article
- Timing of Wnt Inhibition Modulates Directed Differentiation of Medial Ganglionic Eminence Progenitors from Human Pluripotent Stem Cells.Stem cells international · 2018Article
- Motor Neuron Transdifferentiation of Neural Stem Cell from Adipose-Derived Stem Cell Characterized by Differential Gene Expression.Cellular and molecular neurobiology · 2017Article
- Engineering Stem Cell Organoids.Cell stem cell · 2016Review
- Transition toward Human Cytomegalovirus Susceptibility in Early Human Embryonic Stem Cell-Derived Neural Precursors.Journal of virology · 2015Article
- Receptor-interacting protein 140 overexpression promotes neuro-2a neuronal differentiation by ERK1/2 signaling.Chinese medical journal · 2015Article
- The role of microRNAs in human neural stem cells, neuronal differentiation and subtype specification.Cell and tissue research · 2015Review
- Synergistic contribution of SMAD signaling blockade and high localized cell density in the differentiation of neuroectoderm from H9 cells.Biochemical and biophysical research communications · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian central nervous system is a complex neuronal network consisting of a diverse array of cellular subtypes generated in a precise spatial and temporal pattern throughout development. Achieving a greater understanding of the molecular and genetic mechanisms that direct a relatively uniform population of neuroepithelial progenitors into diverse neuronal subtypes remains a significant challenge. The advent of pluripotent stem cell (PSC) technology allows researchers to generate diverse neural populations in vitro. Although the primary focus of PSC-derived neural cells has been their therapeutic potential, utilizing PSCs to study neurodevelopment is another frequently overlooked and equally important application. In this review, we explore the potential for utilizing PSCs to study neural development. We introduce the types of neurodevelopmental questions that PSCs can help to address, and we discuss the different strategies and technologies that researchers use to generate diverse subtypes of PSC-derived neurons. Additionally, we highlight the derivation of several thoroughly characterized neural subtypes; spinal motoneurons, midbrain dopaminergic neurons and cortical neurons. We hope that this review encourages researchers to develop innovative strategies for using PSCs for the study of mammalian, and specifically human, neurodevelopment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.