ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Adult mouse motor units develop almost all of their force in the subprimary range: a new all-or-none strategy for force recruitment?
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Meta-analysis of biological variables' impact on spinal motoneuron electrophysiology data.Journal of neurophysiology · 2020Pooled it
- Machine-learning classification of motor unit types in the adult mouse.The Journal of physiology · 2026Article
- Machine-Learning Classification of Motor Unit Types in the Adult Mouse.bioRxiv : the preprint server for biology · 2025Article
- Motor unit mechanisms of speed control in mouse locomotion.bioRxiv : the preprint server for biology · 2025Article
- A Multi-Scale, High-Fidelity Computational Model of the Mouse Triceps Surae Motor Pool.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- Onion skin is not a universal firing pattern for spinal motoneurons: simulation study.Journal of neurophysiology · 2024Article
- Article
- Electrical Properties of Adult Mammalian Motoneurons.Advances in neurobiology · 2022Article
- From Physiological Properties to Selective Vulnerability of Motor Units in Amyotrophic Lateral Sclerosis.Advances in neurobiology · 2022Article
- Diversity of Mammalian Motoneurons and Motor Units.Advances in neurobiology · 2022Article
- Effective Stimulation Type and Waveform for Force Control of the Motor Unit System: Implications for Intraspinal Microstimulation.Frontiers in neuroscience · 2021Article
- Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes.Current opinion in physiology · 2019Article
- Scaling of Motor Output, From Mouse to Humans.Physiology (Bethesda, Md.) · 2019Review
- The Subprimary Range of Firing Is Present in Both Cat and Mouse Spinal Motoneurons and Its Relationship to Force Development Is Similar for the Two Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- PICs in motoneurons do not scale with the size of the animal: a possible mechanism for faster speed of muscle contraction in smaller species.Journal of neurophysiology · 2017Article
- Neuronal Population Activity in Spinal Motor Circuits: Greater Than the Sum of Its Parts.Frontiers in neural circuits · 2017Review
- Lognormal firing rate distribution reveals prominent fluctuation-driven regime in spinal motor networks.eLife · 2016Article
- Absence of UCHL 1 function leads to selective motor neuropathy.Annals of clinical and translational neurology · 2016Article
- Potassium currents dynamically set the recruitment and firing properties of F-type motoneurons in neonatal mice.Journal of neurophysiology · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Classical studies of the mammalian neuromuscular system have shown an impressive adaptation match between the intrinsic properties of motoneurons and the contractile properties of their motor units. In these studies, the rate at which motoneurons start to fire repetitively corresponds to the rate at which individual twitches start to sum, and the firing rate increases linearly with the amount of excitation ("primary range") up to the point where the motor unit develops its maximal force. This allows for the gradation of the force produced by a motor unit by rate modulation. In adult mouse motoneurons, however, we recently described a regime of firing ("subprimary range") that appears at lower excitation than what is required for the primary range, a finding that might challenge the classical conception. To investigate the force production of mouse motor units, we simultaneously recorded, for the first time, the motoneuron discharge elicited by intracellular ramps of current and the force developed by its motor unit. We showed that the motor unit developed nearly its maximal force during the subprimary range. This was found to be the case regardless of the input resistance of the motoneuron, the contraction speed, or the tetanic force of the motor unit. Our work suggests that force modulation in small mammals mainly relies on the number of motor units that are recruited rather than on rate modulation of individual motor units.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.