ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Nonlinear interactions between excitatory and inhibitory retinal synapses control visual output.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Substance P and dopamine form a "push-pull" system that diurnally regulates retinal gain.Current biology : CB · 2024Article
- Light-evoked glutamate transporter EAAT5 activation coordinates with conventional feedback inhibition to control rod bipolar cell output.Journal of neurophysiology · 2020Article
- Adaptation of Inhibition Mediates Retinal Sensitization.Current biology : CB · 2019Article
- Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells.Scientific reports · 2018Article
- An Amacrine Cell Circuit for Signaling Steady Illumination in the Retina.Cell reports · 2015Article
- Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human Retina.Investigative ophthalmology & visual science · 2015Article
- Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells.The Journal of physiology · 2014Article
- Disinhibitory recruitment of NMDA receptor pathways in retina.Journal of neurophysiology · 2014Article
- Kainate receptors mediate signaling in both transient and sustained OFF bipolar cell pathways in mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Optimized protocol for retinal wholemount preparation for imaging and immunohistochemistry.Journal of visualized experiments : JoVE · 2013Article
- Glycine transporter 1 modulates GABA release from amacrine cells by controlling occupancy of coagonist binding site of NMDA receptors.Journal of neurophysiology · 2013Article
- Independent control of reciprocal and lateral inhibition at the axon terminal of retinal bipolar cells.The Journal of physiology · 2013Article
- Spatial segregation of adaptation and predictive sensitization in retinal ganglion cells.Neuron · 2013Article
- Slow changes in Ca2(+) cause prolonged release from GABAergic retinal amacrine cells.Journal of neurophysiology · 2013Article
- Synaptic mechanisms of adaptation and sensitization in the retina.Nature neuroscience · 2013Article
- A time and cost efficient approach to functional and structural assessment of living neuronal tissue.Journal of neuroscience methods · 2013Article
- Correlated spontaneous activity persists in adult retina and is suppressed by inhibitory inputs.PloS one · 2013Article
- Concentration-invariant odor representation in the olfactory system by presynaptic inhibition.Computational and mathematical methods in medicine · 2013Article
- Paired-pulse plasticity in the strength and latency of light-evoked lateral inhibition to retinal bipolar cell terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The visual system is highly sensitive to dynamic features in the visual scene. However, it is not known how or where this enhanced sensitivity first occurs. We investigated this phenomenon by studying interactions between excitatory and inhibitory synapses in the second synaptic layer of the mouse retina. We found that these interactions showed activity-dependent changes that enhanced signaling of dynamic stimuli. Excitatory signaling from cone bipolar cells to ganglion cells exhibited strong synaptic depression, attributable to reduced glutamate release from bipolar cells. This depression was relieved by amacrine cell inhibitory feedback that activated presynaptic GABA(C) receptors. We found that the balance between excitation and feedback inhibition depended on stimulus frequency; at short interstimulus intervals, excitation was enhanced, attributable to reduced inhibitory feedback. This dynamic interplay may enrich visual processing by enhancing retinal responses to closely spaced temporal events, representing rapid changes in the visual environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.