ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
An olfactory circuit increases the fidelity of visual behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Wind history shapes olfactory search response in free flyingbioRxiv : the preprint server for biology · 2026Article
- Moving in an Uncertain World: Robust and Adaptive Control of Locomotion from Organisms to Machine Intelligence.Integrative and comparative biology · 2024Review
- Divergent visual ecology of Drosophila species drives object-tracking strategies matched to landscape sparsity.Current biology : CB · 2024Article
- The influence of saccades on yaw gaze stabilization in fly flight.PLoS computational biology · 2023Article
- Aversive Bimodal Associations Differently Impact Visual and Olfactory Memory Performance iniScience · 2022Article
- Nonsynaptic Transmission Mediates Light Context-Dependent Odor Responses inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Review
- Bidirectional Regulation of Sleep and Synapse Pruning after Neural Injury.Current biology : CB · 2020Article
- Neuromodulation of insect motion vision.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Insect brain plasticity: effects of olfactory input on neuropil size.Royal Society open science · 2019Article
- Olfactory and Neuromodulatory Signals Reverse Visual Object Avoidance to Approach in Drosophila.Current biology : CB · 2019Article
- Eyes Matched to the Prize: The State of Matched Filters in Insect Visual Circuits.Frontiers in neural circuits · 2018Review
- Olfactory neuromodulation of motion vision circuitry in Drosophila.Current biology : CB · 2015Article
- A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster.eLife · 2015Article
- Multisensory integration of colors and scents: insights from bees and flowers.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Review
- Figure-ground discrimination behavior in Drosophila. I. Spatial organization of wing-steering responses.The Journal of experimental biology · 2014Article
- Odd-skipped labels a group of distinct neurons associated with the mushroom body and optic lobe in the adult Drosophila brain.The Journal of comparative neurology · 2013Article
- Responses of protocerebral neurons in Manduca sexta to sex-pheromone mixtures.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Article
- Parallel pathways for cross-modal memory retrieval in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Multimodal integration allows neural circuits to be activated in a behaviorally context-specific manner. In the case of odor plume tracking by Drosophila, an attractive odorant increases the influence of yaw-optic flow on steering behavior in flight, which enhances visual stability reflexes, resulting in straighter flight trajectories within an odor plume. However, it is not well understood whether context-specific changes in optomotor behavior are the result of an increased sensitivity to motion inputs (e.g., through increased visual attention) or direct scaling of motor outputs (i.e., increased steering gain). We address this question by examining the optomotor behavior of Drosophila melanogaster in a tethered flight assay and demonstrate that whereas olfactory cues decrease the gain of the optomotor response to sideslip optic flow, they concomitantly increase the gain of the yaw optomotor response by enhancing the animal's ability to follow transient visual perturbations. Furthermore, ablating the mushroom bodies (MBs) of the fly brain via larval hydroxyurea (HU) treatment results in a loss of olfaction-dependent increase in yaw optomotor fidelity. By expressing either tetanus toxin light chain or diphtheria toxin in gal4-defined neural circuits, we were able to replicate the loss of function observed in the HU treatment within the lines expressing broadly in the mushroom bodies, but not within specific mushroom body lobes. Finally, we were able to genetically separate the yaw responses and sideslip responses in our behavioral assay. Together, our results implicate the MBs in a fast-acting, memory-independent olfactory modification of a visual reflex that is critical for flight control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.