ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Newborn neurons in the olfactory bulb selected for long-term survival through olfactory learning are prematurely suppressed when the olfactory memory is erased.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system.PLoS biology · 2026Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health.Frontiers in neural circuits · 2024Review
- Neuronal silence as a prosurvival factor for adult-born olfactory bulb interneurons.Stem cell reports · 2023Article
- Olfactory neurogenesis and its role in fear memory modulation.Frontiers in behavioral neuroscience · 2023Review
- Chronic unpredictable mild stress alters odor hedonics and adult olfactory neurogenesis in mice.Frontiers in neuroscience · 2023Article
- Neural processing of the reward value of pleasant odorants.Current biology : CB · 2021Article
- Short-term availability of adult-born neurons for memory encoding.Nature communications · 2019Article
- Running-Activated Neural Stem Cells Enhance Subventricular Neurogenesis and Improve Olfactory Behavior in p21 Knockout Mice.Molecular neurobiology · 2019Article
- Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction.PLoS computational biology · 2019Article
- The role of calretinin-expressing granule cells in olfactory bulb functions and odor behavior.Scientific reports · 2018Article
- Article
- The Functional Role of Olfactory Bulb Granule Cell Subtypes Derived From Embryonic and Postnatal Neurogenesis.Frontiers in molecular neuroscience · 2018Review
- Adult Olfactory Bulb Neurogenesis.Cold Spring Harbor perspectives in biology · 2016Review
- Topographical representation of odor hedonics in the olfactory bulb.Nature neuroscience · 2016Article
- Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury.Experimental neurology · 2016Review
- The Role of Astrocytes in the Generation, Migration, and Integration of New Neurons in the Adult Olfactory Bulb.Frontiers in neuroscience · 2016Review
- Extinction reverses olfactory fear-conditioned increases in neuron number and glomerular size.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- How neurogenesis finds its place in a hardwired sensory system.Frontiers in neuroscience · 2014Review
- The functional significance of newly born neurons integrated into olfactory bulb circuits.Frontiers in neuroscience · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A role for newborn neurons in olfactory memory has been proposed based on learning-dependent modulation of olfactory bulb neurogenesis in adults. We hypothesized that if newborn neurons support memory, then they should be suppressed by memory erasure. Using an ecological approach in mice, we showed that behaviorally breaking a previously learned odor-reward association prematurely suppressed newborn neurons selected to survive during initial learning. Furthermore, intrabulbar infusions of the caspase pan-inhibitor ZVAD (benzyloxycarbonyl-Val-Ala-Asp) during the behavioral odor-reward extinction prevented newborn neurons death and erasure of the odor-reward association. Newborn neurons thus contribute to the bulbar network plasticity underlying long-term memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.