ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
The metabolic regulator PGC-1α directly controls the expression of the hypothalamic neuropeptide oxytocin.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 44 citations in OpenAlex.
- Targeted blocking of gene splicing can dysregulate intron-embedded primary microRNAs.Communications biology · 2026Article
- Development of the neurohypophysis: A major neuroendocrine interface.Journal of neuroendocrinology · 2026Review
- Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes.Frontiers in endocrinology · 2022Review
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- Developmental Effects of Oxytocin Neurons on Social Affiliation and Processing of Social Information.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain.Fish physiology and biochemistry · 2021Article
- Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis.Cell reports · 2020Article
- Review
- The fenestrae-associated protein Plvap regulates the rate of blood-borne protein passage into the hypophysis.Development (Cambridge, England) · 2019Article
- Article
- Genome Editing Reveals Idiosyncrasy of CNGA2 Ion Channel-Directed Antibody Immunoreactivity Toward Oxytocin.Frontiers in cell and developmental biology · 2018Article
- A Filtration-based Method of Preparing High-quality Nuclei from Cross-linked Skeletal Muscle for Chromatin Immunoprecipitation.Journal of visualized experiments : JoVE · 2017Article
- Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children.Journal of clinical research in pediatric endocrinology · 2017Article
- Article
- CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5.Scientific reports · 2016Article
- Role of developmental factors in hypothalamic function.Frontiers in neuroanatomy · 2015Review
- The influences of parental diet and vitamin E intake on the embryonic zebrafish transcriptome.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2014Article
- Oxytocin secretion is related to measures of energy homeostasis in young amenorrheic athletes.The Journal of clinical endocrinology and metabolism · 2014Article
- Role of oxytocin signaling in the regulation of body weight.Reviews in endocrine & metabolic disorders · 2013Review
- Expression of arginine vasotocin receptors in the developing zebrafish CNS.Gene expression patterns : GEP · 2013Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcriptional coactivator PGC-1α is a key regulator of cellular energy expenditure in peripheral tissues. Recent studies report that PGC-1α-null mice develop late-onset obesity and that the neuronal inactivation of PGC-1α causes increased food intake. However, the exact role of PGC-1α in the CNS remains unclear. Here we show that PGC-1α directly regulates the expression of the hypothalamic neuropeptide oxytocin, a known central regulator of appetite. We developed a unique genetic approach in the zebrafish, allowing us to monitor and manipulate PGC-1α activity in oxytocinergic neurons. We found that PGC-1α is coexpressed with oxytocin in the zebrafish hypothalamus. Targeted knockdown of the zebrafish PGC-1α gene activity caused a marked decrease in oxytocin mRNA levels and inhibited the expression of a transgenic GFP reporter driven by the oxytocin promoter. The effect of PGC-1α loss of function on oxytocin gene activity was rescued by tissue-specific re-expression of either PGC-1α or oxytocin precursor in zebrafish oxytocinergic neurons. PGC-1α activated the oxytocin promoter in a heterologous cell culture system, and overexpression of PGC-1α induced ectopic expression of oxytocin in muscles and neurons. Finally, PGC-1α forms an in vivo complex with the oxytocin promoter in fed but not fasted animals. These findings demonstrate that PGC-1α is both necessary and sufficient for the production of oxytocin, implicating hypothalamic PGC-1α in the direct activation of a hypothalamic hormone known to control energy intake.
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