ArticleCerebral cortex (New York, N.Y. : 1991)2012
Regional cortical thinning associated with detectable levels of HIV DNA.
Article in Cerebral cortex (New York, N.Y. : 1991), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Brain Structural Changes following HIV Infection: Meta-Analysis.AJNR. American journal of neuroradiology · 2018Pooled it
- Resting-state neural signatures of depressive symptoms in acute HIV.Journal of neurovirology · 2020Trial
- Comorbid HIV and Cocaine Use Exacerbate Accelerated Brain Aging.bioRxiv : the preprint server for biology · 2026Article
- Cortical folding pattern of asymptomatic HIV-associated neurocognitive disorders.BMC medical imaging · 2025Article
- Effects of Human Immunodeficiency Virus Infection and Former Cocaine Dependence on Neuroanatomical Measures and Neurocognitive Performance.Neuroscience · 2022Article
- Altered Glymphatic System in Middle-Aged cART-Treated Patients With HIV: A Diffusion Tensor Imaging Study.Frontiers in neurology · 2022Article
- Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension.Translational psychiatry · 2021Article
- A hidden menace? Cytomegalovirus infection is associated with reduced cortical gray matter volume in major depressive disorder.Molecular psychiatry · 2021Article
- Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection.Scientific reports · 2021Observational
- Connectivity-informed adaptive regularization for generalized outcomes.The Canadian journal of statistics = Revue canadienne de statistique · 2021Article
- EEG event related potentials in sustained, focused and divided attention tasks: Potential biomarkers for cognitive impairment in HIV patients.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit.PloS one · 2021Article
- Whole-brain computational modeling reveals disruption of microscale brain dynamics in HIV infected individuals.Human brain mapping · 2021Article
- The association of peripheral immune markers with brain cortical thickness and surface area in South African people living with HIV.Journal of neurovirology · 2020Article
- A longitudinal study of brain volume changes in rhesus macaque model infected with SIV.Journal of neurovirology · 2020Article
- Logistic Regression Confined by Cardinality-Constrained Sample and Feature Selection.IEEE transactions on pattern analysis and machine intelligence · 2020Article
- Mass Spectrometry Imaging Demonstrates the Regional Brain Distribution Patterns of Three First-Line Antiretroviral Drugs.ACS omega · 2019Article
- HIV infection and age effects on striatal structure are additive.Journal of neurovirology · 2019Article
- Rilpivirine as a potential candidate for the treatment of HIV-associated neurocognitive disorders (HAND).Journal of molecular histology · 2019Article
- Novel Machine Learning Identifies Brain Patterns Distinguishing Diagnostic Membership of Human Immunodeficiency Virus, Alcoholism, and Their Comorbidity of Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
High levels of human immunodeficiency virus (HIV) DNA in peripheral blood mononuclear cells (PBMCs), and specifically within CD14+ blood monocytes, have been found in HIV-infected individuals with neurocognitive impairment and dementia. The failure of highly active antiretroviral therapy (HAART) to eliminate cognitive dysfunction in HIV may be secondary to persistence of HIV-infected PBMCs which cross the blood-brain barrier, leading to perivascular inflammation and neuronal injury. This study assessed brain cortical thickness relative to HIV DNA levels and identified, we believe for the first time, a neuroimaging correlate of detectable PBMC HIV DNA in subjects with undetectable HIV RNA. Cortical thickness was compared between age- and education-matched groups of older (>40 years) HIV-seropositive subjects on HAART who had detectable (N = 9) and undetectable (N = 10) PBMC HIV DNA. Statistical testing revealed highly significant (P < 0.001) cortical thinning associated with detectable HIV DNA. The largest regions affected were in bilateral insula, orbitofrontal and temporal cortices, right superior frontal cortex, and right caudal anterior cingulate. Cortical thinning correlated significantly with a measure of psychomotor speed. The areas of reduced cortical thickness are key nodes in cognitive and emotional processing networks and may be etiologically important in HIV-related neurological deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.