Evidence map›Paper›PMID 22016447›Full record

ReviewAmerican journal of respiratory and critical care medicine2012

Vitamin D and asthma.

Grace Paul, John M Brehm, John F Alcorn, Fernando Holguín, Shean J Aujla, Juan C Celedón

Open access · greenAbstract readReview
In one paragraph

Review in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 3 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Association of free vitamin DAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018
    Trial
  5. Trial
  6. Prevalence and risk factors for allergic rhinitis in two resource-limited settings in Peru with disparate degrees of urbanization.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015
    Trial
  7. 25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015
    Trial
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Post-Transplant Vitamin D Deficiency in Lung Transplant Recipients: Impact on Outcomes and Prognosis.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Observational
  15. The Role of Vitamins in the Pathogenesis of Asthma.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Grace PaulDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pennsylvania, USA.
John M Brehm
John F Alcorn
Fernando Holguín
Shean J Aujla
Juan C Celedón
University of Pittsburgh · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Genes, Home Allergens and Asthma Puerto Rican ChildrenR01HL079966 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2006 to 2010
$3.8M
NCATS NIH HHS UL1 TR000454NHLBI NIH HHS HL079966NHLBI NIH HHS R01 HL079966
6 · The paper itself

Abstract

Vitamin D deficiency and asthma are common conditions that share risk factors such as African American ethnicity, inner-city residence, and obesity. This review provides a critical examination of current experimental and epidemiologic evidence of a causal association between vitamin D status and asthma or asthma morbidity, including potential protective mechanisms such as antiviral effects and enhanced steroid responsiveness. Because most published epidemiologic studies of vitamin D and asthma or asthma morbidity are observational, a recommendation for or against vitamin D supplementation as preventive or secondary treatment for asthma is not advisable and must await results of ongoing clinical trials. Should these trials confirm a beneficial effect of vitamin D, others will be needed to assess the role of vitamin D supplementation to prevent or treat asthma in different groups such as infants, children of school age, and ethnic minorities.

Indexed as

AsthmaBone Density Conservation AgentsEvidence-Based MedicineHumansRisk FactorsTreatment OutcomeUnited StatesVitamin DVitamin D DeficiencyBone Density Conservation AgentsVitamin D

Identifiers

PMID22016447
PMCPMC3297088
OpenAlexW2170018246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.