ArticleAmerican journal of respiratory and critical care medicine2012
Neurogenic changes in the upper airway of patients with obstructive sleep apnea.
Article in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Assessment and rehabilitation of tongue motor skills with myofunctional therapy in obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Pooled it
- The Role of Incretins in Obstructive Sleep Apnea "GLP1RAs and GLP1RA/GIPRAs in OSA".Journal of diabetes · 2025Article
- Geometrically-engineered human motor assembloids-on-a-chip for neuromuscular interaction readout and hypoxia-driven disease modeling.Nature communications · 2025Article
- Diagnostic Accuracy of an Orofacial Scale for the Detection of Orofacial Myofunctional Disorders in Patients With Obstructive Sleep Apnoea.Journal of oral rehabilitation · 2025Article
- Deep learning enhanced transmembranous electromyography in the diagnosis of sleep apnea.BMC neuroscience · 2024Article
- Article
- Chronic Intermittent Hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production.bioRxiv : the preprint server for biology · 2024Article
- Regional associations between inspiratory tongue dilatory movement and genioglossus activity during wakefulness in people with obstructive sleep apnoea.The Journal of physiology · 2023Article
- Arginine vasopressin potentiates inspiratory bursting in hypoglossal motoneurons of neonatal mice.Respiratory physiology & neurobiology · 2023Article
- Sleep Apnea, Obesity, and Diabetes - an Intertwined Trio.Current diabetes reports · 2023Review
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Effect of Obesity on Masticatory Muscle Activity and Rhythmic Jaw Movements Evoked by Electrical Stimulation of Different Cortical Masticatory Areas.Journal of clinical medicine · 2023Article
- Moderate-to-severe obstructive sleep apnea syndrome is associated with altered tongue motion during wakefulness.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Beyond CPAP: modifying upper airway output for the treatment of OSA.Frontiers in neurology · 2023Review
- Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig.PloS one · 2023Article
- The role of neuromuscular function in sleep apnea pathogenesis and management: A consensus of experts.Frontiers in sleep · 2023Review
- Role of PGC-1α in fiber type conversion in the palatopharyngeus muscle of OSA patients.Journal of clinical laboratory analysis · 2022Article
- The impact of daytime transoral neuromuscular stimulation on upper airway physiology - A mechanistic clinical investigation.Physiological reports · 2022Article
- Reduced Cross-Frequency Coupling and Daytime Sleepiness in Obstructive Sleep Apnea Patients.Biology · 2022Article
- Myopathy of the upper airway in snoring and obstructive sleep apnea.Laryngoscope investigative otolaryngology · 2022Article
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Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
Abstract
rationaleControversy persists regarding the presence and importance of hypoglossal nerve dysfunction in obstructive sleep apnea (OSA).
objectivesWe assessed quantitative parameters related to motor unit potential (MUP) morphology derived from electromyographic (EMG) signals in patients with OSA versus control subjects and hypothesized that signs of neurogenic remodeling would be present in the patients with OSA.
methodsParticipants underwent diagnostic sleep studies to obtain apnea-hypopnea indices. Muscle activity was detected with 50-mm concentric needle electrodes. The concentric needle was positioned at more than 10 independent sites per subject, after the local anatomy of the upper airway musculature was examined by ultrasonography. All activity was quantified with subjects awake, during supine eupneic breathing while wearing a nasal mask connected to a pneumotachograph. Genioglossus EMG signals were analyzed offline by automated software (DQEMG), which extracted motor unit potential trains (MUPTs) contributed by individual motor units from the composite EMG signals. Quantitative measurements of MUP templates, including duration, peak-to-peak amplitude, area, area-to-amplitude ratio, and size index, were compared between the untreated patients with OSA and healthy control subjects. MEASUREMENTS AND MAIN
resultsA total of 1,655 MUPTs from patients with OSA (n = 17; AHI, 55 ± 6/h) and control subjects (n = 14; AHI, 4 ± 1/h) were extracted from the genioglossus muscle EMG signals. MUP peak-to-peak amplitudes in the patients with OSA were not different compared with the control subjects (397.5 ± 9.0 vs. 382.5 ± 10.0 μV). However, the MUPs of the patients with OSA were longer in duration (11.5 ± 0.1 vs. 10.3 ± 0.1 ms; P < 0.001) and had a larger size index (4.09 ± 0.02 vs. 3.92 ± 0.02; P < 0.001) compared with control subjects.
conclusionsThese results confirm and quantify the extent and existence of structural neural remodeling in OSA.
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