ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Hedgehog signaling in the posterior region of the mouse gastrula suggests manifold roles in the fetal-umbilical connection and posterior morphogenesis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- The mouse allantois: new insights at the embryonic-extraembryonic interface.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo.The EMBO journal · 2022Article
- Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Visceral endoderm and the primitive streak interact to build the fetal-placental interface of the mouse gastrula.Developmental biology · 2017Article
- Sonic hedgehog (SHH) signaling improves the angiogenic potential of Wharton's jelly-derived mesenchymal stem cells (WJ-MSC).Stem cell research & therapy · 2017Article
- Brachyury drives formation of a distinct vascular branchpoint critical for fetal-placental arterial union in the mouse gastrula.Developmental biology · 2017Article
- STELLA collaborates in distinct mesendodermal cell subpopulations at the fetal-placental interface in the mouse gastrula.Developmental biology · 2017Article
- PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Insights into blood cell formation from hemogenic endothelium in lesser-known anatomic sites.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Mixl1 localizes to putative axial stem cell reservoirs and their posterior descendants in the mouse embryo.Gene expression patterns : GEP · 2014Article
- From dinosaurs to birds: a tail of evolution.EvoDevo · 2014Review
- Mouse primordial germ cells: a reappraisal.International review of cell and molecular biology · 2014Review
- Widespread but tissue-specific patterns of interferon-induced transmembrane protein 3 (IFITM3, FRAGILIS, MIL-1) in the mouse gastrula.Gene expression patterns : GEP · 2013Article
- Mapping mouse hemangioblast maturation from headfold stages.Developmental biology · 2012Article
- The hypoblast (visceral endoderm): an evo-devo perspective.Development (Cambridge, England) · 2012Review
- STELLA-positive subregions of the primitive streak contribute to posterior tissues of the mouse gastrula.Developmental biology · 2012Article
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2 authors at 1 institution in 1 country.
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Abstract
Although many fetal birth defects, particularly those of the body wall and gut, are associated with abnormalities of the umbilical cord, the developmental relationship between these structures is largely obscure. Recently, genetic analysis of mid-gestation mouse embryos revealed that defects in Hedgehog signaling led to omphalocoele, or failure of the body wall to close at the umbilical ring (Matsumaru et al. [ 2011] PLos One 6:e16260). However, systematic spatiotemporal localization of Hedgehog signaling in the allantois, or umbilical precursor tissue, and the surrounding regions has not been documented. Here, a combination of reagents, including the Ptc1:lacZ and Runx1:lacZ reporter mice, immunohistochemistry for Smoothened (Smo), Sonic Hedgehog (Shh), and Indian hedgehog (Ihh), and detailed PECAM-1/Flk-1/Runx-1 analysis, revealed robust Hedgehog signaling in previously undocumented posterior sites over an extended period of time (∼7.0-9.75 dpc). These included the recently described proximal walls of the allantois (Ventral and Dorsal Cuboidal Mesothelia; VCM and DCM, respectively); the ventral embryonic surface continuous with them; hemogenic arterial endothelia; hematopoietic cells; the hindgut; ventral ectodermal ridge (VER); chorionic ectoderm; and the intraplacental yolk sac (IPY), which appeared to be a site of placental hematopoiesis. This map of Hedgehog signaling in the posterior region of the mouse conceptus will provide a valuable foundation upon which to elucidate the origin of many posterior midline abnormalities, especially those of the umbilical cord and associated fetal defects. Developmental Dynamics 240:2175-2193, 2011. © 2011 Wiley-Liss, Inc.
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