ArticleJournal of biotechnology2012
Synthetic Escherichia coli consortia engineered for syntrophy demonstrate enhanced biomass productivity.
Article in Journal of biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Diffusion-based mechanism explains spatial organization in cross-feeding biofilms.NPJ biofilms and microbiomes · 2025Article
- CRISPRi-mediated metabolic switch enables concurrent aerobic and synthetic anaerobic fermentations in engineered consortium.Nature communications · 2024Article
- Plant Growth-Promoting Bacteria of Soil: Designing of Consortia Beneficial for Crop Production.Microorganisms · 2023Review
- Discovery of novel amino acid production traits by evolution of synthetic co-cultures.Microbial cell factories · 2023Article
- Evidence of a possible multicellular life cycle iniScience · 2023Article
- Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective.Open biology · 2022Review
- Guided by the principles of microbiome engineering: Accomplishments and perspectives for environmental use.mLife · 2022Review
- Article
- Resource-aware whole-cell model of division of labour in a microbial consortium for complex-substrate degradation.Microbial cell factories · 2022Article
- Construction of Environmental Synthetic Microbial Consortia: Based on Engineering and Ecological Principles.Frontiers in microbiology · 2022Review
- Causes and consequences of pattern diversification in a spatially self-organizing microbial community.The ISME journal · 2021Article
- Emerging Molecular Tools for Engineering Phytomicrobiome.Indian journal of microbiology · 2021Review
- Global dynamics of the chemostat with overflow metabolism.Journal of mathematical biology · 2021Article
- Automated design of synthetic microbial communities.Nature communications · 2021Article
- Pseudomonas aeruginosa reverse diauxie is a multidimensional, optimized, resource utilization strategy.Scientific reports · 2021Article
- Artificial consortium demonstrates emergent properties of enhanced cellulosic-sugar degradation and biofuel synthesis.NPJ biofilms and microbiomes · 2020Article
- Biohydrogen production beyond the Thauer limit by precision design of artificial microbial consortia.Communications biology · 2020Article
- Majority sensing in synthetic microbial consortia.Nature communications · 2020Article
- The microbial exometabolome: ecological resource and architect of microbial communities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Interaction-dependent effects of surface structure on microbial spatial self-organization.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Synthetic Escherichia coli consortia engineered for syntrophy demonstrated enhanced biomass productivity relative to monocultures. Binary consortia were designed to mimic a ubiquitous, naturally occurring ecological template of primary productivity supported by secondary consumption. The synthetic consortia replicated this evolution-proven strategy by combining a glucose positive E. coli strain, which served as the system's primary producer, with a glucose negative E. coli strain which consumed metabolic byproducts from the primary producer. The engineered consortia utilized strategic division of labor to simultaneously optimize multiple tasks enhancing overall culture performance. Consortial interactions resulted in the emergent property of enhanced system biomass productivity which was demonstrated with three distinct culturing systems: batch, chemostat and biofilm growth. Glucose-based biomass productivity increased by ∼15, 20 and 50% compared to appropriate monoculture controls for these three culturing systems, respectively. Interestingly, the consortial interactions also produced biofilms with predictable, self-assembling, laminated microstructures. This study establishes a metabolic engineering paradigm which can be easily adapted to existing E. coli based bioprocesses to improve productivity based on a robust ecological theme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.