Evidence map›Paper›PMID 22015874›Full record

ArticleObstetrics and gynecology2011

Gestational glucose tolerance and maternal metabolic profile at 3 years postpartum.

Alison M Stuebe, Christos Mantzoros, Ken Kleinman, Matthew W Gillman, Sheryl Rifas-Shiman, Ellen W Seely, Janet Rich-Edwards

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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  6. Adverse Pregnancy Outcomes and Future Metabolic Syndrome.Journal of women's health (2002) · 2023
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  11. Observational
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  14. Review
  15. Cohort profile: project viva.International journal of epidemiology · 2015
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alison M StuebeFrom the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, and the Department of Maternal and Child Health, Gillings Global School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and the Department of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, the Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, the Departments of Nutrition and Epidemiology, Harvard School of Public Health, the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and the Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Brigham Circle, Boston, Massachusetts.
Christos Mantzoros
Ken Kleinman
Matthew W Gillman
Sheryl Rifas-Shiman
Ellen W Seely
Janet Rich-Edwards
Beth Israel Deaconess Medical Center · USHarvard University Press · USUniversity of North Carolina at Chapel Hill · US

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
NUTRITION IN PREGNANCY, BIRTH WEIGHT, &CHILDHOOD ASTHMAR01HL064925 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2000 to 2010
$7.5M
Pre- and Peri-natal Predictors of Childhood ObesityR37HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2012 to 2015
$4.5M
Maternal fatty acids, child obesity, and asthma immunityR01HL075504 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2004 to 2007
$2.4M
Lactation and diabetes risk factors in womenR21DK073739 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI RICH-EDWARDS, JANET W · 2006 to 2007
$459k
NHLBI NIH HHS HL 064925NHLBI NIH HHS HL 075504NHLBI NIH HHS R01 HL064925NHLBI NIH HHS R01 HL075504NICHD NIH HHS R01 HD 034568NICHD NIH HHS R01 HD034568NICHD NIH HHS R37 HD034568NIDDK NIH HHS R21 DK053537NIDDK NIH HHS R21 DK073739
6 · The paper itself

Abstract

objectiveTo estimate the independent effect of gestational impaired glucose tolerance, defined as a single abnormal oral glucose tolerance test value, on metabolic dysfunction at 3 years postpartum.

methodsWe used multiple linear regression to measure associations between glucose testing during pregnancy and metabolic markers at 3 years postpartum in Project Viva, a prospective cohort study of maternal and infant health. We compared metabolic measures at 3 years postpartum among four groups: normal glucose challenge test (less than 140 mg/dL, n=461); abnormal glucose challenge test but normal glucose tolerance test (n=39); impaired glucose tolerance (a single abnormal glucose tolerance test value, n=21); and gestational diabetes mellitus (n=16).

resultsAdjusting for age, race, parity, parental history of diabetes, and maternal body mass index at 3 years postpartum, we found women with gestational diabetes mellitus had lower adiponectin (11.2 ng/mL compared with 20.7 ng/mL) and higher homeostatic model assessments of insulin resistance (3.1 compared with 1.3) and waist circumference (91.3 cm compared with 86.2 cm) compared with women with impaired glucose tolerance or normal glucose tolerance. Women in both the impaired glucose tolerance and gestational diabetes mellitus groups had lower high-density lipoprotein (gestational diabetes mellitus 44.7 mg/dL; impaired glucose tolerance 45.4/dL compared with normal glucose tolerance 55.8 mg/dL) and higher triglycerides (gestational diabetes mellitus 136.1 mg/dL; impaired glucose tolerance 140.1 mg/dL compared with normal glucose tolerance 78.3) compared with women in the normal glucose tolerance group. We found the highest values for hemoglobin A1c (gestational diabetes mellitus 5.1%, impaired glucose tolerance 5.3%, normal glucose tolerance 5.1%) and high-sensitivity C-reactive protein (gestational diabetes mellitus 1.4 mg/dL, impaired glucose tolerance 2.2 mg/dL, normal glucose tolerance 1.0 mg/dL) among women with impaired glucose tolerance.

conclusionGestational diabetes mellitus and impaired glucose tolerance during pregnancy are associated with persistent metabolic dysfunction at 3 years postpartum, independent of other clinical risk factors.

Indexed as

AdultDiabetes, GestationalFemaleGlucose Tolerance TestHumansLinear ModelsPostpartum PeriodPregnancyTime Factors

Identifiers

PMID22015874
PMCPMC3268071
OpenAlexW1979439085

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.