ArticleEMBO reports2011
Fast transcription rates of RNA polymerase II in human cells.
Article in EMBO reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed.
- Temporal gating dictates stress-induced transcript export from the nucleus.Genes & development · 2026Article
- Lack of evidence for transcription-to-RNA maturation lags across G1-to-G2-phase boundary in fibroblasts.Life science alliance · 2026Article
- Temporal gating dictates stress-induced transcript export from the nucleus.bioRxiv : the preprint server for biology · 2026Article
- Co-transcriptional splicing facilitates transcription of gigantic genes.PLoS genetics · 2024Article
- Following the tracks: How transcription factor binding dynamics control transcription.Biophysical journal · 2022Review
- Slow nucleosome dynamics set the transcriptional speed limit and induce RNA polymerase II traffic jams and bursts.PLoS computational biology · 2022Article
- RNA polymerase II speed: a key player in controlling and adapting transcriptome composition.The EMBO journal · 2021Review
- Altering transcription factor binding reveals comprehensive transcriptional kinetics of a basic gene.Nucleic acids research · 2021Article
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- Changes of Gene Expression in Euglena gracilis Obtained During the 29Scientific reports · 2019Article
- Satellite DNA-containing gigantic introns in a unique gene expression program during Drosophila spermatogenesis.PLoS genetics · 2019Article
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- Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes.PLoS pathogens · 2018Review
- Transcriptional Homeostasis of Oxidative Stress-Related Pathways in Altered Gravity.International journal of molecular sciences · 2018Article
- Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells.Scientific reports · 2018Article
- Conformational profiling of a G-rich sequence within the c-KIT promoter.Nucleic acids research · 2017Article
- Detection of human immunodeficiency virus RNAs in living cells using Spinach RNA aptamers.Virus research · 2017Article
- Interfacing Neural Network Components and Nucleic Acids.Frontiers in bioengineering and biotechnology · 2017Review
- Transcription Dynamics in Living Cells.Annual review of biophysics · 2016Review
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7 authors.
Funding
Abstract
Averaged estimates of RNA polymerase II (RNAPII) elongation rates in mammalian cells have been shown to range between 1.3 and 4.3 kb min(-1). In this work, nascent RNAs from an integrated human immunodeficiency virus type 1-derived vector were detectable at the single living cell level by fluorescent RNA tagging. At steady state, a constant number of RNAs was measured corresponding to a minimal density of polymerases with negligible fluctuations over time. Recovery of fluorescence after photobleaching was complete within seconds, indicating a high rate of RNA biogenesis. The calculated transcription rate above 50 kb min(-1) points towards a wide dynamic range of RNAPII velocities in living cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.