ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2012
Identification and characterization of a novel outer membrane protein receptor required for hemin utilization in Vibrio vulnificus.
Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Proteomic analysis reveals the adaptation of Vibrio splendidus to an iron deprivation condition.Applied microbiology and biotechnology · 2023Article
- Article
- Characterization of temperature-dependent hemin uptake receptors HupA and HvtA in Vibrio vulnificus.MicrobiologyOpen · 2019Article
- Article
- Vibrio Iron Transport: Evolutionary Adaptation to Life in Multiple Environments.Microbiology and molecular biology reviews : MMBR · 2016Review
- Host-nonspecific iron acquisition systems and virulence in the zoonotic serovar of Vibrio vulnificus.Infection and immunity · 2014Article
- Role and regulation of heme iron acquisition in gram-negative pathogens.Frontiers in cellular and infection microbiology · 2013Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vibrio vulnificus, the cause of septicemia and serious wound infection in humans and fishes, require iron for its pathogenesis. Hemin uptake through the outer membrane receptor, HupA, is one of its many mechanisms by which it acquires iron. We report here the identification of an additional TonB-dependent hemin receptor HvtA, that is needed in conjunction with the HupA protein for optimal hemin utilization. The HvtA protein is significantly homologous to other outer membrane hemin receptors and its expression in trans restored the uptake of hemin and hemoglobin, the latter to a weaker extent, in a mutant strain that was defective in both receptors. Quantitative RT-PCR suggested that transcription of the hvtA gene was iron regulated. The operon containing the hvtA gene is homologous to the operon in V. cholerae containing the hemin receptor gene hutR suggesting a vertical transmission of the hvtA cluster from V. cholerae to V. vulnificus.
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Registered trials
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