Trial reportPublic health nutrition2012
Predictors of anaemia and iron deficiency in HIV-infected pregnant women in Tanzania: a potential role for vitamin D and parasitic infections.
Trial report in Public health nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Antihelminthics in helminth-endemic areas: effects on HIV disease progression.The Cochrane database of systematic reviews · 2016Pooled it
- The association between malaria and iron status or supplementation in pregnancy: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Antiretroviral Treatment Is Associated With Iron Deficiency in HIV-Infected Malawian Women That Is Mitigated With Supplementation, but Is Not Associated With Infant Iron Deficiency During 24 Weeks of Exclusive Breastfeeding.Journal of acquired immune deficiency syndromes (1999) · 2015Trial
- Haemoglobin status and predictors of anaemia among pregnant women in Mpigi, Uganda.BMC research notes · 2014Trial
- Hormones in malaria infection: influence on disease severity, host physiology, and therapeutic opportunities.Bioscience reports · 2024Review
- Article
- Article
- Slower response to treatment of iron-deficiency anaemia in pregnant women infected with HIV: a prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2021Article
- Article
- Anemia and Micronutrient Status during Pregnancy, and Their Associations with Obstetric and Infant Outcomes among HIV-Infected Ugandan Women Receiving Antiretroviral Therapy.Current developments in nutrition · 2020Article
- Tropical Parasitic Infections in Individuals Infected with HIV.Current tropical medicine reports · 2017Article
- Lower incidence of respiratory infections among iron-deficient children in Kilimanjaro, Tanzania.Evolution, medicine, and public health · 2017Article
- Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya.Nutrients · 2016Article
- Determinants of Anemia Among Human Immunodeficiency Virus-Positive Adults at Care and Treatment Clinics in Dar es Salaam, Tanzania.The American journal of tropical medicine and hygiene · 2016Article
- Vitamin D Status Affects Serum Metabolomic Profiles in Pregnant Adolescents.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Eliminating preventable HIV-related maternal mortality in sub-Saharan Africa: what do we need to know?Journal of acquired immune deficiency syndromes (1999) · 2014Review
- Pregnancy and helminth infections.Parasite immunology · 2014Review
- Hemoglobin concentration and parasitemia on hospital admission predict risk of multiple organ dysfunction syndrome among adults with malaria.The American journal of tropical medicine and hygiene · 2014Article
- Prevalence of malaria and anaemia among HIV infected pregnant women receiving co-trimoxazole prophylaxis in Tanzania: a cross sectional study in Kinondoni Municipality.BMC pharmacology & toxicology · 2014Article
- Exploring gender dimensions of treatment programmes for neglected tropical diseases in Uganda.PLoS neglected tropical diseases · 2013Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveAnaemia is common during pregnancy, and prenatal Fe supplementation is the standard of care. However, the persistence of anaemia despite Fe supplementation, particularly in HIV infection, suggests that its aetiology may be more complex and warrants further investigation. The present study was conducted to examine predictors of incident haematological outcomes in HIV-infected pregnant women in Tanzania.
designProspective cohort study. Cox proportional hazards and binomial regression models were used to identify predictors of incident haematological outcomes: anaemia (Hb < 110 g/l), severe anaemia (Hb < 85 g/l) and hypochromic microcytosis, during the follow-up period.
settingAntenatal clinics in Dar es Salaam, Tanzania. SUBJECTS: Participants were 904 HIV-infected pregnant women enrolled in a randomized trial of vitamins (1995-1997).
resultsMalaria, pathogenic protozoan and hookworm infections at baseline were associated with a two-fold increase in the risk of anaemia and hypochromic microcytosis during follow-up. Higher baseline erythrocyte sedimentation rate and CD8 T-cell concentrations, and lower Hb concentrations and CD4 T-cell counts, were independent predictors of incident anaemia and Fe deficiency. Low baseline vitamin D (<32 ng/ml) concentrations predicted a 1.4 and 2.3 times greater risk of severe anaemia and hypochromic microcytosis, respectively, during the follow-up period.
conclusionsParasitic infections, vitamin D insufficiency, low CD4 T-cell count and high erythrocyte sedimentation rate were the main predictors of anaemia and Fe deficiency in pregnancy and the postpartum period in this population. A comprehensive approach to prevent and manage anaemia, including micronutrient supplementation and infectious disease control, is warranted in HIV-infected women in resource-limited settings - particularly during the pre- and postpartum periods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.