ArticleMolecular pharmaceutics2011
In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activity.
Article in Molecular pharmaceutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Analysis of Matrix Metalloproteinase Activity and Inhibition in Cancer Spheroids.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression.International journal of molecular sciences · 2021Review
- Targeting MMP-14 for dual PET and fluorescence imaging of glioma in preclinical models.European journal of nuclear medicine and molecular imaging · 2020Article
- Recent progress in the imaging detection of enzyme activitiesRSC advances · 2019Review
- Development of Radiolabeled Membrane Type-1 Matrix Metalloproteinase Activatable Cell Penetrating Peptide Imaging Probes.Molecules (Basel, Switzerland) · 2015Article
- Development of a Radiolabeled Peptide-Based Probe Targeting MT1-MMP for Breast Cancer Detection.PloS one · 2015Article
- Novel 19F activatable probe for the detection of matrix metalloprotease-2 activity by MRI/MRS.Molecular pharmaceutics · 2014Article
- Rational design of matrix metalloproteinase-13 activatable probes for enhanced specificity.ACS chemical biology · 2014Article
- Article
- Visualization of protease activity in vivo using an activatable photo-acoustic imaging probe based on CuS nanoparticles.Theranostics · 2014Article
- Noninvasive monitoring of pulmonary fibrosis by targeting matrix metalloproteinases (MMPs).Molecular pharmaceutics · 2013Article
- Targeting tumor hypoxia with 2-nitroimidazole-indocyanine green dye conjugates.Journal of biomedical optics · 2013Article
- Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers.Cancer science · 2013Article
- Interrogating tumor metabolism and tumor microenvironments using molecular positron emission tomography imaging. Theranostic approaches to improve therapeutics.Pharmacological reviews · 2013Review
- PET imaging of inflammation biomarkers.Theranostics · 2013Review
- Chemical biology for understanding matrix metalloproteinase function.Chembiochem : a European journal of chemical biology · 2012Review
- Activatable near-infrared fluorescent probe for in vivo imaging of fibroblast activation protein-alpha.Bioconjugate chemistry · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Herein we demonstrate for the first time that a fluorogenic probe can be used as an in vivo imaging agent for visualizing activities of membrane-tethered, membrane-type matrix metalloproteinases (MT-MMPs). An MT-MMP fluorogenic probe that consisted of an MT1-MMP (MMP-14) substrate and near-infrared (NIR) dye-quencher pair exhibited rapid, efficient boosts in fluorescence upon cleavage by MT1-MMP in tumor-bearing mice. In particular, unlike similar fluorogenic probes designed to target extracellular, soluble-type MMPs (EC-MMPs)--which can be cleared from the bloodstream after activation--the fluorescence signals activated by MT1-MMP enable clear visualization of MT1-MMP-positive tumors in animal models for up to 24 h. The results indicate that a simple form of a fluorogenic probe that is less effective in EC-MMP imaging is an effective probe for imaging MT-MMP activities in vivo. These findings can be widely applied to designing probes and to applications targeting various membrane-anchored proteases in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.