ArticleBMC complementary and alternative medicine2011
Antioxidant, antimicrobial and anticancer activity of the lichens Cladonia furcata, Lecanora atra and Lecanora muralis.
Article in BMC complementary and alternative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A review of the potential of lichen substances as antifungal agents: the effects of extracts and lichen secondary metabolites on Fusarium fungi.Archives of microbiology · 2022Pooled it
- The effect of lichen secondary metabolites on Aspergillus fungi.Archives of microbiology · 2021Pooled it
- Unveiling Lichen's Hidden Arsenal Against Multidrug Resistance: A Systematic Review of Their Essential Oils, Volatile Compounds and Extracts with Antimicrobial Applications.Microorganisms · 2026Review
- Arctic lichen Cladonia borealis-induced cell death is mediated by p53-independent activation of Caspase-9 and PARP-1 signaling in human colorectal cancer cell lines.Journal of microbiology (Seoul, Korea) · 2025Article
- GC-MS Profiling and Pharmacological Potential ofTurkish journal of pharmaceutical sciences · 2024Article
- De novo mitochondrial genome sequencing of Cladonia subulata and phylogenetic analysis with other dissimilar species.PloS one · 2023Article
- UHPLC-MS Chemical Fingerprinting and Antioxidant, Enzyme Inhibition, Anti-Inflammatory In Silico and Cytoprotective Activities ofAntioxidants (Basel, Switzerland) · 2022Article
- Comparative study amongSaudi journal of biological sciences · 2022Article
- Antimicrobial and antioxidant potentials of non-cytotoxic extracts of corticolous lichens sampled in Armenia.AMB Express · 2021Article
- The metabolite 5-methyl-1,3-benzenediol and its derivative methyl-2,4-dihydroxy-6-methylbenzoate from the lichen3 Biotech · 2021Article
- Tropical lichen, Dirinaria consimilis, induces ROS-mediated activation of MAPKs and triggers caspase cascade mediated apoptosis in brain and cervical cancer cells.Molecular and cellular biochemistry · 2021Article
- Antioxidant, antimicrobial and cytotoxicity potential of n-hexane extract of Cayratia trifolia L.Bioinformation · 2021Article
- Greener pathway toward the synthesis of lichen-based ZnO@TiOFood science & nutrition · 2020Article
- Pigment production by Fusarium solani BRM054066 and determination of antioxidant and anti-inflammatory properties.AMB Express · 2020Article
- Differential anti-proliferative and apoptotic effects of lichen species on human prostate carcinoma cells.PloS one · 2020Article
- Epanorin, a lichen secondary metabolite, inhibits proliferation of MCF-7 breast cancer cells.Biological research · 2019Article
- Oxidative stress mediated by gyrophoric acid from the lichen Umbilicaria hirsuta affected apoptosis and stress/survival pathways in HeLa cells.BMC complementary and alternative medicine · 2019Article
- Antibacterial and anticancer activities of acetone extracts from in vitro cultured lichen-forming fungi.BMC complementary and alternative medicine · 2017Article
- Fungal and Bacterial Pigments: Secondary Metabolites with Wide Applications.Frontiers in microbiology · 2017Review
- Lasallia pustulata lichen as possible natural antigenotoxic, antioxidant, antimicrobial and anticancer agent.Cytotechnology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study is to investigate in vitro antioxidant, antimicrobial and anticancer activity of the acetone extracts of the lichens Cladonia furcata, Lecanora atra and Lecanora muralis.
methodsAntioxidant activity was evaluated by five separate methods: free radical scavenging, superoxide anion radical scavenging, reducing power, determination of total phenolic compounds and determination of total flavonoid content. The antimicrobial activity was estimated by determination of the minimal inhibitory concentration by the broth microdilution method against six species of bacteria and ten species of fungi. Anticancer activity was tested against FemX (human melanoma) and LS174 (human colon carcinoma) cell lines using MTT method.
resultsOf the lichens tested, Lecanora atra had largest free radical scavenging activity (94.7% inhibition), which was greater than the standard antioxidants. Moreover, the tested extracts had effective reducing power and superoxide anion radical scavenging. The strong relationships between total phenolic and flavonoid contents and the antioxidant effect of tested extracts were observed. Extract of Cladonia furcata was the most active antimicrobial agent with minimum inhibitory concentration values ranging from 0.78 to 25 mg/mL. All extracts were found to be strong anticancer activity toward both cell lines with IC(50) values ranging from 8.51 to 40.22 μg/mL.
conclusionsThe present study shows that tested lichen extracts demonstrated a strong antioxidant, antimicrobial and anticancer effects. That suggest that lichens may be used as as possible natural antioxidant, antimicrobial and anticancer agents to control various human, animal and plant diseases.
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