Evidence map›Paper›PMID 22013504›Full record

ArticleJournal of transplantation2011

Molecular imaging: a promising tool to monitor islet transplantation.

Ping Wang, Zdravka Medarova, Anna Moore

Open access · goldAbstract read
In one paragraph

Article in Journal of transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ping WangMolecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Zdravka Medarova
Anna Moore
Harvard University · US

Funding

Pre-clinical in vivo imaging of islet transplantation in non-human primatesR01DK078615 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MOORE, ANNA · 2007 to 2011
$2.6M
Combined siRNA Therapy and In-vivo Imaging in Islet TransplantationR01DK080784 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MOORE, ANNA · 2008 to 2011
$1.5M
In-Vivo Imaging of Islet TransplantationR01DK072137 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MOORE, ANNA · 2006 to 2009
$1.4M
NIDDK NIH HHS R01 DK072137NIDDK NIH HHS R01 DK078615NIDDK NIH HHS R01 DK080784
6 · The paper itself

Abstract

Replacement of insulin production by pancreatic islet transplantation has great potential as a therapy for type 1 diabetes mellitus. At present, the lack of an effective approach to islet grafts assessment limits the success of this treatment. The development of molecular imaging techniques has the potential to fulfill the goal of real-time noninvasive monitoring of the functional status and viability of the islet grafts. We review the application of a variety of imaging modalities for detecting endogenous and transplanted beta-cell mass. The review also explores the various molecular imaging strategies for assessing islet delivery, the metabolic effects on the islet grafts as well as detection of immunorejection. Here, we highlight the use of combined imaging and therapeutic interventions in islet transplantation and the in vivo monitoring of stem cells differentiation into insulin-producing cells.

Identifiers

PMID22013504
PMCPMC3195545
OpenAlexW1967104852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.