ArticleDose-response : a publication of International Hormesis Society2011
Cognitive activation by central thalamic stimulation: the yerkes-dodson law revisited.
Article in Dose-response : a publication of International Hormesis Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Montreal Cognitive Assessment Hearing Impairment (MoCA-H) in brazilian portuguese: performance analysis.CoDAS · 2026Observational
- Review
- The effect of high-intensity intermittent and moderate-intensity continuous exercises on neurobiological markers and cognitive performance.BMC sports science, medicine & rehabilitation · 2024Article
- Luvadaxistat: A Novel Potent and Selective D-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia.Neurochemical research · 2023Article
- Breast cancer and breast cancer screening use-beliefs and behaviours in a nationwide study in Malaysia.BMC public health · 2023Article
- Moderate white light exposure enhanced spatial memory retrieval by activating a central amygdala-involved circuit in mice.Communications biology · 2023Article
- Impairment of aversive episodic memories during Covid-19 pandemic: The impact of emotional context on memory processes.Neurobiology of learning and memory · 2022Article
- Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates.Scientific reports · 2021Article
- Threat-Modulation of Executive Functions-A Novel Biomarker of Depression?Frontiers in psychiatry · 2021Article
- Methamphetamine seeking after prolonged abstinence is associated with activated projections from anterior intralaminar nucleus of thalamus to dorsolateral striatum in female rats.Pharmacology, biochemistry, and behavior · 2021Article
- Effort Displayed During Appetitive Phase of Feeding Behavior Requires Infralimbic Cortex Activity and Histamine H1 Receptor Signaling.Frontiers in neuroscience · 2019Article
- Modulation of Theta-Band Local Field Potential Oscillations Across Brain Networks With Central Thalamic Deep Brain Stimulation to Enhance Spatial Working Memory.Frontiers in neuroscience · 2019Article
- Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Editorial: Extreme Environments in Movement Science and Sport Psychology.Frontiers in psychology · 2018Article
- Illuminating Neural Circuits: From Molecules to MRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Midline thalamic reuniens lesions improve executive behaviors.Neuroscience · 2017Article
- Robust modulation of arousal regulation, performance, and frontostriatal activity through central thalamic deep brain stimulation in healthy nonhuman primates.Journal of neurophysiology · 2016Article
- Central thalamic deep brain stimulation to support anterior forebrain mesocircuit function in the severely injured brain.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- The Contribution of Equitation Science to Minimising Horse-Related Risks to Humans.Animals : an open access journal from MDPI · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central thalamus regulates forebrain arousal, influencing activity in distributed neural networks that give rise to organized actions during alert, wakeful states. Central thalamus has been implicated in working memory by the effects of lesions and microinjected drugs in this part of the brain. Lesions and drugs that inhibit neural activity have been found to impair working memory. Drugs that increase activity have been found to enhance and impair memory depending on the dose tested. Electrical deep brain stimulation (DBS) similarly enhances working memory at low stimulating currents and impairs it at higher currents. These effects are time dependent. They were observed when DBS was applied during the memory delay (retention) or choice response (retrieval) but not earlier in trials during the sample (acquisition) phase. The effects of microinjected drugs and DBS are consistent with the Yerkes-Dodson law, which describes an inverted-U relationship between arousal and behavioral performance. Alternatively these results may reflect desensitization associated with higher levels of stimulation, spread of drugs or current to adjacent structures, or activation of less sensitive neurons or receptors at higher DBS currents or drug doses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.