ArticleJournal of biomedicine & biotechnology2011
The evolution of the mitochondria-to-calcium release units relationship in vertebrate skeletal muscles.
Article in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling.The Journal of cell biology · 2014Trial
- Mitochondrial Activity Localization in the Skeletal Muscle and Its Individual Fibers Across Tetrapods.Biology of the cell · 2026Article
- Elevation of Mitochondrial CaCells · 2026Article
- Review
- Intracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease.Endocrine reviews · 2023Review
- Excitation-contraction coupling in mammalian skeletal muscle: Blending old and last-decade research.Frontiers in physiology · 2022Review
- The location of InsP3 receptors in Purkinje cells of murine cerebellum does not supports a direct interaction in the transfer of calcium ions between ER and mitochondria.European journal of translational myology · 2021Article
- Ageing Causes Ultrastructural Modification to Calcium Release Units and Mitochondria in Cardiomyocytes.International journal of molecular sciences · 2021Article
- Calcium entry units (CEUs): perspectives in skeletal muscle function and disease.Journal of muscle research and cell motility · 2021Article
- Impact of Mitophagy and Mitochondrial Unfolded Protein Response as New Adaptive Mechanisms Underlying Old Pathologies: Sarcopenia and Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2020Review
- Role of Age-Related Mitochondrial Dysfunction in Sarcopenia.International journal of molecular sciences · 2020Review
- Review
- Elongated mitochondrial constrictions and fission in muscle fatigue.Journal of cell science · 2018Article
- Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA.Journal of cell science · 2018Article
- Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Antioxidant Treatment Reduces Formation of Structural Cores and Improves Muscle Function in RYR1Oxidative medicine and cellular longevity · 2017Article
- Age-dependent uncoupling of mitochondria from Ca2⁺ release units in skeletal muscle.Oncotarget · 2015Article
- Specific association of growth-associated protein 43 with calcium release units in skeletal muscles of lower vertebrates.European journal of histochemistry : EJH · 2014Article
- The excitation-contraction coupling mechanism in skeletal muscle.Biophysical reviews · 2014Review
- The location of energetic compartments affects energetic communication in cardiomyocytes.Frontiers in physiology · 2014Article
Corrections and comments
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2 authors.
Funding
Abstract
The spatial relationship between mitochondria and the membrane systems, more specifically the calcium release units (CRUs) of skeletal muscle, is of profound functional significance. CRUs are the sites at which Ca(2+) is released from the sarcoplasmic reticulum during muscle activation. Close mitochondrion-CRU proximity allows the organelles to take up Ca(2+) and thus stimulate aerobic metabolism. Skeletal muscles of most mammals display an extensive, developmentally regulated, close mitochondrion-CRU association, fostered by tethering links between the organelles. A comparative look at the vertebrate subphylum however shows that this specific association is only present in the higher vertebrates (mammals). Muscles in all other vertebrates, even if capable of fast activity, rely on a less precise and more limited mitochondrion-CRU proximity, despite some tethering connections. This is most evident in fish muscles. Clustering of free subsarcolemmal mitochondria in proximity of capillaries is also more frequently achieved in mammalian than in other vertebrates.
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