ArticleThe Journal of infectious diseases2011
Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Urinary albumin-to-creatinine ratio is associated with endothelial dysfunction in HIV-infected patients receiving antiretroviral therapy.Scientific reports · 2016Trial
- High prevalence of albuminuria among adult males living with HIV in Botswana.Scientific reports · 2024Observational
- Association of Kidney Disease With Abnormal Cardiac Structure and Function Among Ugandans With HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2021Article
- Hypertension in HIV-Infected Adults: Novel Pathophysiologic Mechanisms.Hypertension (Dallas, Tex. : 1979) · 2018Review
- Microvascular endothelial dysfunction is associated with albuminuria and CKD in older adults.BMC nephrology · 2016Observational
- Markers of renal disease and function are associated with systemic inflammation in HIV infection.HIV medicine · 2015Article
- Relationships between renal parameters and serum and urine markers of inflammation in those with and without HIV infection.AIDS research and human retroviruses · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
It is unknown whether systemic endothelial dysfunction underlies the association between nephropathy and cardiovascular disease (CVD) in persons infected with human immunodeficiency virus (HIV). Spot urine protein to creatinine ratio, spot urine albumin to creatinine ratio, creatinine clearance, estimated glomerular filtration rate, and flow-mediated dilation (FMD) of the brachial artery were evaluated in 123 study participants infected with HIV (58 receiving antiretroviral therapy [ART] and 65 not receiving ART) with no history of diabetes or hypertension. None of the renal markers, modeled as either continuous or categorical variables, correlated with FMD. Contrary to expectations, endothelial dysfunction may not be the link between nephropathy and CVD in HIV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.