ArticleBiological research for nursing2013
The relationships between FAM5C SNP (rs10920501) variability and metabolic syndrome and inflammation in women with coronary heart disease.
Article in Biological research for nursing, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 6 citations in OpenAlex.
- Effects of CDKN2B-AS1 polymorphisms on the susceptibility to coronary heart disease.Molecular genetics & genomic medicine · 2019Article
- Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans.American journal of human genetics · 2017Article
- Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease.Human genomics · 2016Article
- Genome-wide association study identifies loci and candidate genes for meat quality traits in Simmental beef cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
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2 authors at 2 institutions in 1 country.
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Abstract
introductionThe leading cause of death among women is coronary heart disease (CHD), a multifactorial disease with polygenic heritability estimated at 50%. Polymorphisms in the family with sequence similarity 5, member C' (FAM5C) gene have been associated with myocardial infarction (MI). FAM5C also corresponds directly with the inflammatory biomarker monocyte chemoattractant protein 1 (MCP-1) and metabolic syndrome.
methodThe purpose of this descriptive gene association pilot study was to investigate the variability of FAM5C (rs10920501) in 91 women with CHD. The authors also examined the associations between the variability of FAM5C (rs10920501) and metabolic syndrome, inflammatory markers, and early onset CHD.
resultsNo women in this study with the homozygous variant (TT) had an MI. Women with a history of MI and the heterozygous (AT) genotype had a later age of onset of CHD compared to those with the homozygous wild type (AA; F(3, 34) = 5.00, p < .01). These findings suggest a protective effect of the T allele in women with a history of MI. The genotype of FAM5C rs10920501 explained approximately 7% of the variability of age of onset of CHD in women who have had an MI, while holding body mass index (BMI) and smoking history constant. There was no significant relationship between FAM5C (rs10920501) and metabolic syndrome or any inflammatory biomarkers in this sample.
conclusionFAM5C remains a gene of interest in a complex disease process.
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