ArticleJournal of virology2012
Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 32 citations in OpenAlex.
- CD8ɑ+ cells suppress SIV replication without the development of mutations within MHC class-I-restricted epitopes during post-treatment control.Journal of virology · 2026Article
- CD8ɑ+ cells suppress SIV replication without evidence of viral immune escape during post treatment control.bioRxiv : the preprint server for biology · 2025Article
- Review
- Within-host diversity of SARS-CoV-2 lineages and effect of vaccination.Research square · 2022Article
- Pre-existing Simian Immunodeficiency Virus Infection Increases Expression of T Cell Markers Associated with Activation during EarlyJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Article
- Preexisting Simian Immunodeficiency Virus Infection Increases Susceptibility to Tuberculosis in Mauritian Cynomolgus Macaques.Infection and immunity · 2018Article
- Acute-Phase CD4Journal of virology · 2018Article
- Rhesus Macaques Are More Susceptible to Progressive Tuberculosis than Cynomolgus Macaques: a Quantitative Comparison.Infection and immunity · 2018Article
- Within-Epitope Interactions Can Bias CTL Escape Estimation in Early HIV Infection.Frontiers in immunology · 2017Article
- Pre-infection transcript levels of FAM26F in peripheral blood mononuclear cells inform about overall plasma viral load in acute and post-acute phase after simian immunodeficiency virus infection.The Journal of general virology · 2016Article
- Vaccination with Live Attenuated Simian Immunodeficiency Virus (SIV) Protects from Mucosal, but Not Necessarily Intravenous, Challenge with a Minimally Heterologous SIV.Journal of virology · 2016Article
- Investigating the Consequences of Interference between Multiple CD8+ T Cell Escape Mutations in Early HIV Infection.PLoS computational biology · 2016Article
- Conditional Immune Escape during Chronic Simian Immunodeficiency Virus Infection.Journal of virology · 2016Article
- LayerCake: a tool for the visual comparison of viral deep sequencing data.Bioinformatics (Oxford, England) · 2015Article
- Within-host nucleotide diversity of virus populations: insights from next-generation sequencing.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Review
- The Effect of Interference on the CD8(+) T Cell Escape Rates in HIV.Frontiers in immunology · 2014Article
- Measuring turnover of SIV DNA in resting CD4+ T cells using pyrosequencing: implications for the timing of HIV eradication therapies.PloS one · 2014Article
- Indel and Carryforward Correction (ICC): a new analysis approach for processing 454 pyrosequencing data.Bioinformatics (Oxford, England) · 2013Article
- Acute-phase CD8 T cell responses that select for escape variants are needed to control live attenuated simian immunodeficiency virus.Journal of virology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
CD8+ T cell responses rapidly select viral variants during acute human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection. We used pyrosequencing to examine variation within three SIV-derived epitopes (Gag₃₈₆₋₃₉₄GW9, Nef₁₀₃₋₁₁₁RM9, and Rev₅₉₋₆₈SP10) targeted by immunodominant CD8+ T cell responses in acutely infected Mauritian cynomolgus macaques. In animals recognizing all three epitopes, variation within Rev₅₉₋₆₈SP10 was associated with delayed accumulation of variants in Gag₃₈₆₋₃₉₄GW9 but had no effect on variation within Nef₁₀₃₋₁₁₁RM9. This demonstrates that the entire T cell repertoire, rather than a single T cell population, influences the timing of immune escape, thereby providing the first example of conditional CD8+ T cell escape in HIV/SIV infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.