ArticleCardiovascular research2012
Oxygen cycling in conjunction with stem cell transplantation induces NOS3 expression leading to attenuation of fibrosis and improved cardiac function.
Article in Cardiovascular research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Oxygen physiology and mechanisms of oxygen toxicity: a narrative review.Medical gas research · 2026Review
- The Role of Hyperbaric Oxygen Therapy in Neuroregeneration and Neuroprotection: A Review.Cureus · 2024Review
- The new insights of hyperbaric oxygen therapy: focus on inflammatory bowel disease.Precision clinical medicine · 2024Review
- Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics.Redox biology · 2022Review
- A critical review of fibrous polyurethane-based vascular tissue engineering scaffolds.Journal of biological engineering · 2022Review
- Oxygen Delivery Approaches to Augment Cell Survival After Myocardial Infarction: Progress and Challenges.Cardiovascular toxicology · 2022Review
- PTEN as a Therapeutic Target in Pulmonary Hypertension Secondary to Left-heart Failure: Effect of HO-3867 and Supplemental Oxygenation.Cell biochemistry and biophysics · 2021Review
- Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation.Molecular medicine reports · 2021Article
- High oxygen preservation hydrogels to augment cell survival under hypoxic condition.Acta biomaterialia · 2020Article
- PEDF protects cardiomyocytes by promoting FUNDC1‑mediated mitophagy via PEDF-R under hypoxic condition.International journal of molecular medicine · 2018Article
- An Injectable Oxygen Release System to Augment Cell Survival and Promote Cardiac Repair Following Myocardial Infarction.Scientific reports · 2018Article
- Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction.Frontiers in cardiovascular medicine · 2018Article
- Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative colitis: a prospective case series.BMJ open gastroenterology · 2016Article
- MicroRNA-133a engineered mesenchymal stem cells augment cardiac function and cell survival in the infarct heart.Journal of cardiovascular pharmacology · 2015Article
- Hyperbaric oxygen, vasculogenic stem cells, and wound healing.Antioxidants & redox signaling · 2014Review
- Gene expression analysis reveals inhibition of radiation-induced TGFβ-signaling by hyperbaric oxygen therapy in mouse salivary glands.Molecular medicine (Cambridge, Mass.) · 2014Article
- The stem cell adjuvant with Exendin-4 repairs the heart after myocardial infarction via STAT3 activation.Journal of cellular and molecular medicine · 2014Article
- CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage.Stem cell research · 2014Article
- Article
- p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.EMBO molecular medicine · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
aimsMyocardial infarction (MI) is associated with irreversible loss of viable cardiomyocytes. Cell therapy is a potential option to replace the lost cardiomyocytes and restore cardiac function. However, cell therapy is faced with a number of challenges, including survival of the transplanted cells in the infarct region, which is characterized by abundant levels of oxidants and lack of a pro-survival support mechanism. The goal of the present study was to evaluate the effect of supplemental oxygenation on cell engraftment and functional recovery in a rat model. METHODS AND
resultsMI was induced in rats by a 60-min occlusion of the coronary artery, followed by restoration of flow. Mesenchymal stem cells (MSCs), isolated from adult rat bone marrow, were transplanted in the MI region. Rats with transplanted MSCs were exposed to hyperbaric oxygen (HBO: 100% O(2), 2 atmospheres absolute) for 90 min, 5 days/week for 4 weeks. The experimental groups were: MI (control), Ox (MI + HBO), MSC (MI + MSC), and MSC + Ox (MI + MSC + HBO). HBO exposure (oxygenation) was started 3 days after induction of MI. MSCs were transplanted 1 week after induction of MI. Echocardiography showed a significant recovery of cardiac function in the MSC + Ox group, when compared with the MI or MSC group. Oxygenation increased the engraftment of MSCs and vascular density in the infarct region. Molecular analysis of infarct tissue showed a four-fold increase in NOS3 expression in the MSC + Ox group compared with the MI group.
conclusionsThe results showed that post-MI exposure of rats to daily cycles of hyperoxygenation (oxygen cycling) improved stem cell engraftment, cardiac function, and increased NOS3 expression.
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Registered trials
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