ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2012
Ventricular function during exercise in mice and rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- AAV-microutrophin gene therapy confers durable cardioprotection against pharmacologic and exercise-induced injury in the mdx mouse.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Rescue and Translocation of Hispaniola Hutia (Ecology and evolution · 2024Article
- Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites.Science advances · 2024Article
- What to consider for ECG in mice-with special emphasis on telemetry.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- Body Surface Potential Mapping during Ventricular Depolarization in Rats after Acute Exhaustive Exercise.Arquivos brasileiros de cardiologia · 2022Article
- Animal Models of Exercise From Rodents to Pythons.Circulation research · 2022Review
- Impaired Myocardial Energetics Causes Mechanical Dysfunction in Decompensated Failing Hearts.Function (Oxford, England) · 2020Article
- Effects of Rodent Thermoregulation on Animal Models in the Research Environment.Comparative medicine · 2018Review
- Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.Molecular cancer research : MCR · 2018Article
- Unanesthetized Rodents Demonstrate Insensitivity of QT Interval and Ventricular Refractory Period to Pacing Cycle Length.Frontiers in physiology · 2018Article
- Article
- Fundamental hemodynamic mechanisms mediating the response to myocardial ischemia in conscious paraplegic mice: cardiac output versus peripheral resistance.Physiological reports · 2017Article
- Complex and interacting influences of the autonomic nervous system on cardiac electrophysiology in conscious mice.Autonomic neuroscience : basic & clinical · 2016Article
- In vivo mouse myocardial (31)P MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations.NMR in biomedicine · 2015Article
- The 24 h pattern of arterial pressure in mice is determined mainly by heart rate-driven variation in cardiac output.Physiological reports · 2014Article
- Reperfusion-induced sustained ventricular tachycardia, leading to ventricular fibrillation, in chronically instrumented, intact, conscious mice.Physiological reports · 2014Article
- Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.Circulation · 2014Article
- Cardiac electrophysiology and the susceptibility to sustained ventricular tachycardia in intact, conscious mice.American journal of physiology. Heart and circulatory physiology · 2014Article
- Small and large animal models in cardiac contraction research: advantages and disadvantages.Pharmacology & therapeutics · 2014Review
- Dynamic interaction between the heart and its sympathetic innervation following T5 spinal cord transection.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The mouse has many advantages over other experimental models for the molecular investigation of left ventricular (LV) function. Accordingly, there is a keen interest in, as well as an intense need for, a conscious, chronically instrumented, freely moving mouse model for the determination of cardiac function. To address this need, we used a telemetry device for repeated measurements of LV function in conscious mice at rest and during exercise. For reference, we compared the responses in mice to the responses in identically instrumented conscious rats. The transmitter body of the telemetry device (rat PA-C40; mouse PA-C10; Data Sciences International, St. Paul, MN) was placed in the intraperitoneal space through a ventral abdominal approach (rat) or subcutaneously on the left flank (mouse). The pressure sensor, located within the tip of a catheter, was inserted into the left ventricle through an apical stab wound (18 gauge for rat; 21 gauge for mouse) for continuous, nontethered, recordings of pulsatile LV pressure. A minimum of 1 wk was allowed for recovery and for the animals to regain their presurgical weight. During the recovery period, the animals were handled, weighed, and acclimatized to the laboratory, treadmill, and investigators. Subsequently, LV parameters were recorded at rest and during a graded exercise test. The results document, for the first time, serial assessment of ventricular function during exercise in conscious mice and rats. This methodology may be adopted for advancing the concepts and ideas that drive cardiovascular research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.