ArticleEuropean journal of nuclear medicine and molecular imaging2012
Direct relationship between cell density and FDG uptake in asymptomatic aortic aneurysm close to surgical threshold: an in vivo and in vitro study.
Article in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Molecular imaging of aortic fibroblast activation protein throughEuropean journal of nuclear medicine and molecular imaging · 2026Article
- The Genoa Vascular Biobank: A Today Resource for Future Perspectives in Vascular Research.Biomarker insights · 2025Article
- Association between PET/CT Scan Findings, Treatment, and Cancer Incidence in a Cohort of AAA Patients.Journal of clinical medicine · 2024Article
- Abdominal Aortic Aneurysm and PET/CT: From Molecular Mechanisms to Potential Molecular Imaging Targets.Reviews in cardiovascular medicine · 2023Review
- Prospect of positron emission tomography for abdominal aortic aneurysm risk stratification.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Review
- Imaging Biological Pathways in Abdominal Aortic Aneurysms Using Positron Emission Tomography.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Nanoparticle-Assisted Diagnosis and Treatment for Abdominal Aortic Aneurysm.Frontiers in medicine · 2021Review
- Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis.EJNMMI research · 2020Article
- Abdominal aortic aneurysms.Nature reviews. Disease primers · 2018Review
- Role of PET/CT in the Evaluation of Aortic Disease.Chonnam medical journal · 2018Review
- Role of molecular imaging with positron emission tomographic in aortic aneurysms.Journal of thoracic disease · 2017Review
- Cross-Sectional Imaging to Evaluate the Risk of Rupture in Abdominal Aortic Aneurysms: Review article based on a dissertation submitted to fulfill the academic grade of doctor in medical sciences (….), entitled: Imaging the mechanisms involved in abdominal aortic aneurysms rupture; a step towards patient-specific risk assessment.Journal of the Belgian Society of Radiology · 2016Article
- Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification.Circulation. Cardiovascular imaging · 2016Review
- (18)F-FDG PET scanning of abdominal aortic aneurysms and correlation with molecular characteristics: a systematic review.EJNMMI research · 2015Article
- 18F-FDG PET-CT uptake is a feature of both normal diameter and aneurysmal aortic wall and is not related to aneurysm size.European journal of nuclear medicine and molecular imaging · 2014Article
- Utility of (18) F-FDG and (11)C-PBR28 microPET for the assessment of rat aortic aneurysm inflammation.EJNMMI research · 2014Article
- Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer.Cell cycle (Georgetown, Tex.) · 2013Article
- Molecular imaging in atherosclerosis: FDG PET.Current atherosclerosis reports · 2012Review
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeConflicting results have been reported about the clinical value of fluorodeoxyglucose (FDG) imaging in predicting the risk of rupture of abdominal aortic aneurysm (AAA). The present study tests the hypothesis that FDG uptake is low in asymptomatic noninflammatory AAA due to the low cell density in aneurysmal walls.
methodsPositron emission tomography (PET)/CT imaging was performed in 12 consecutive candidates for AAA surgical repair and in 12 age- and sex-matched controls. At intervention, aneurysmal walls were cut into three sequential blocks. Block A was frozen to cut three 5-μm slices for incubation with 2-3 MBq of FDG for 5 min. Block C was first incubated with the same tracer solution for the same time and subsequently frozen to cut three 5-μm slices. Autoradiographic images were coregistered with immunohistochemical pictures of cell density, type and DNA synthesis as assessed on block B.
resultsNo visible uptake in abdominal aorta occurred in any patient or control subject. Immunohistochemistry documented a severe loss of wall structure, with low numbers of cells. Tracer retention directly correlated with overall cell density and with prevalence of cells synthesizing DNA. The metabolic nature of FDG uptake was confirmed by the selective effect of preliminary freezing that decreased tracer content by 90% in regions with high cell density and only by 34% in cold acellular areas.
conclusionThe loss of tissue structure and the marked decrease in cell density account for the low prevalence of positive findings at FDG PET imaging, at least in asymptomatic patients bearing AAAs whose diameter is close to surgical indication.
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