ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Childhood adversity increases risk for nicotine dependence and interacts with α5 nicotinic acetylcholine receptor genotype specifically in males.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Pooled it
- Genotype × Environment Interaction in Smoking Behaviors: A Systematic Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Pooled it
- Child marriage and risky health behaviors: an analysis of tobacco use among early adult and early middle-aged women in India.BMC women's health · 2022Article
- Identification of susceptibility variants to benign childhood epilepsy with centro-temporal spikes (BECTS) in Chinese Han population.EBioMedicine · 2020Article
- Associations between child maltreatment, cigarette smoking, and nicotine dependence in young adults with a history of regular smoking.Annals of epidemiology · 2019Article
- Early life adversity influences stress response association with smoking relapse.Psychopharmacology · 2017Article
- Genetics of addictive behavior: the example of nicotine dependence.Dialogues in clinical neuroscience · 2017Review
- Unpacking the impact of adverse childhood experiences on adult mental health.Child abuse & neglect · 2017Article
- Childhood life events, immune activation and the development of mood and anxiety disorders: the TRAILS study.Translational psychiatry · 2017Article
- New Empirical Evidence on the Validity and the Reliability of the Early Life Stress Questionnaire in a Polish Sample.Frontiers in psychology · 2017Article
- Impairment of contextual fear extinction by chronic nicotine and withdrawal from chronic nicotine is associated with hippocampal nAChR upregulation.Neuropharmacology · 2016Article
- Life adversity is associated with smoking relapse after a quit attempt.Addictive behaviors · 2016Article
- Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.Molecular psychiatry · 2016Review
- Childhood adversity interacts with adult stressful events to predict reduced likelihood of smoking cessation among women but not men.Clinical psychological science : a journal of the Association for Psychological Science · 2016Article
- The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity.Current opinion in endocrinology, diabetes, and obesity · 2016Review
- Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.Molecular neurobiology · 2016Review
- Nicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans.Neuropharmacology · 2015Review
- Genetic influences on nicotinic α5 receptor (CHRNA5) CpG methylation and mRNA expression in brain and adipose tissue.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2015Article
- Childhood adversity moderates the effect of ADH1B on risk for alcohol-related phenotypes in Jewish Israeli drinkers.Addiction biology · 2015Article
- The Genetics, Neurogenetics and Pharmacogenetics of Addiction.Current behavioral neuroscience reports · 2014Article
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
The relative importance of specific genetic and environmental factors in regulating nicotine dependence (ND) risk, including the effects on specific forms of childhood adversity on smoking risk, have been understudied. Genome-wide association studies and rodent models have demonstrated that the α5 nicotinic acetylcholine receptor gene (CHRNA5) is important in regulating nicotine intake. Childhood adversity increases the methylation level of the CHRNA5 promoter region in European Americans (EAs), an effect that was observed only in males (Zhang et al, submitted for publication). In view of this potential sex difference in the effects of early life experience on smoking, we investigated the presence of a sex-specific gene-by-environment effect of this marker on ND risk. A nonsynonymous SNP in CHRNA5 previously associated to ND and several related traits, rs16969968, was genotyped in 2206 EAs (1301 men and 905 women). The main and interactive effects of childhood adversity and rs16969968 genotype on diagnosis of ND and ND defined by dichotomized Fagerstrom test for ND (FTND) scores were explored. Men and women were analyzed separately to test for sex differences. Childhood adversity significantly increased ND risk in both sexes, and the effect in women was twice than that in men. Significant interactive effects of childhood adversity and rs16969968 genotype were observed in men (ND: OR=1.80, 95% CI=1.18-2.73, P=0.0044; FTND: OR=1.79, 95% CI=1.11-2.88, P=0.012). No interaction was found in women. This study provides evidence of a sex-specific gene × environment effect of CHRNA5 and childhood adversity on the risk for ND.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.