ArticleClinical oral investigations2012
Periodontal inflamed surface area and C-reactive protein as predictors of HbA1c: a study in Indonesia.
Article in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of periodontitis in people clinically diagnosed with diabetes mellitus: a meta-analysis of epidemiologic studies.Acta diabetologica · 2021Pooled it
- Periodontal inflamed surface area (PISA) system and components: Potential for exploring the periodontal systemic interface.Journal of periodontology · 2026Article
- Periodontal markers predict glycemic control in diabetic patients a ten year retrospective analysis.Scientific reports · 2025Article
- The Association of Periodontal Inflammation and Systemic Health Indicators: A Machine Learning Approach.Journal of clinical periodontology · 2025Article
- Dental-implant inflamed surface area: A quantification and simulation study.Journal of periodontology · 2025Article
- Article
- Glycemic Control, Inflammatory Mediators, and Periodontal Health: A Cross-Sectional Study in Patients with Diabetes.Journal of clinical medicine · 2025Article
- Assessment of the association between coronary artery blockage and periodontal health status in patients undergoing coronary angiography: a cross-sectional study.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Relationship between type II diabetes mellitus and oral health status among middle-aged iranians patients.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Association between Clinical Periodontal Features and Glycated Hemoglobin in Patients with Diabetes and Controlled Periodontitis: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
- Development of a Japanese Version of the Formula for Calculating Periodontal Inflamed Surface Area: A Simulation Study.International journal of environmental research and public health · 2022Article
- Enzymatic measurement of short-chain fatty acids and application in periodontal disease diagnosis.PloS one · 2022Article
- Association of periodontitis and diabetic macular edema in various stages of diabetic retinopathy.Clinical oral investigations · 2022Article
- Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2021Article
- The Associations of Periodontopathic Bacteria and Oral Candida with Periodontal Inflamed Surface Area in Older Adults Receiving Supportive Periodontal Therapy.Diagnostics (Basel, Switzerland) · 2021Article
- Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study.Scientific reports · 2021Article
- Relationship Between Halitosis and Periodontitis: a Pilot Study.Acta stomatologica Croatica · 2021Article
- Bidirectional Association between Metabolic Control in Type-2 Diabetes Mellitus and Periodontitis Inflammatory Burden: A Cross-Sectional Study in an Italian Population.Journal of clinical medicine · 2021Article
- Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination.Journal of clinical medicine · 2021Article
- Association of Periodontal Status, Number of Teeth, and Obesity: A Cross-Sectional Study in Japan.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledPeriodontitis may exert an infectious and inflammatory burden, evidenced by increased C-reactive protein (CRP). This burden may impair blood glucose control (HbA1c). The aim of our study was to analyze whether periodontitis severity as measured with the periodontal inflamed surface area (PISA) and CRP predict HbA1c levels in a group of healthy Indonesians and a group of Indonesians treated for type 2 diabetes mellitus (DM2). A full-mouth periodontal examination, including probing pocket depth, gingival recession, clinical attachment loss, plaque index and bleeding on probing, was performed in 132 healthy Indonesians and 101 Indonesians treated for DM2. Using these data, PISA was calculated. In addition, HbA1c and CRP were analyzed. A validated questionnaire was used to assess smoking, body mass index (BMI), education and medical conditions. In regression analyses, it was assessed whether periodontitis severity and CRP predict HbA1c, controlling for confounding and effect modification (i.e., age, sex, BMI, pack years, and education). In healthy Indonesians, PISA and CRP predicted HbA1c as did age, sex, and smoking. In Indonesians treated for DM2, PISA did not predict HbA1c. Periodontitis may impair blood glucose regulation in healthy Indonesians in conjunction with elevated CRP levels. The potential effect of periodontitis on glucose control in DM2 patients may be masked by DM2 treatment. CLINICAL RELEVANCE: periodontitis may impair blood glucose control through exerting an inflammatory and infectious burden evidenced by increased levels of CRP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.