ArticleNature2011
Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon.
Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 97 citations in OpenAlex.
- Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026Review
- Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β-carbonic anhydrase.FEBS letters · 2025Article
- Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions.bioRxiv : the preprint server for biology · 2024Article
- Amplicon-guided isolation and cultivation of previously uncultured microbial species from activated sludge.Applied and environmental microbiology · 2023Article
- Fungal Carbonyl Sulfide Hydrolase of Trichoderma harzianum Strain THIF08 and Its Relationship with Clade D β-Carbonic Anhydrases.Microbes and environments · 2021Article
- Zeta-carbonic anhydrases show CSComputational and structural biotechnology journal · 2021Article
- Enumeration of Chemoorganotrophic Carbonyl Sulfide (COS)-degrading Microorganisms by the Most Probable Number Method.Microbes and environments · 2020Article
- Hydrogen and Carbon Monoxide-UtilizingFrontiers in microbiology · 2020Article
- Soil carbonyl sulfide exchange in relation to microbial community composition: insights from a managed grassland soil amendment experiment.Soil biology & biochemistry · 2019Article
- Asp305Gly mutation improved the activity and stability of the styrene monooxygenase for efficient epoxide production in Pseudomonas putida KT2440.Microbial cell factories · 2019Article
- Diversity and Distribution of Sulfur Oxidation-Related Genes inFrontiers in microbiology · 2019Article
- Cooperative adsorption of carbon disulfide in diamine-appended metal-organic frameworks.Nature communications · 2018Article
- Emerging Roles of Carbonyl Sulfide in Chemical Biology: Sulfide Transporter or Gasotransmitter?Antioxidants & redox signaling · 2018Review
- Resurrecting ancestral genes in bacteria to interpret ancient biosignatures.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Article
- Isotopic Fractionation of Sulfur in Carbonyl Sulfide by Carbonyl Sulfide Hydrolase of Thiobacillus thioparus THI115.Microbes and environments · 2017Article
- X-ray Structure of Catenated Lytic Transglycosylase SltB1.Biochemistry · 2017Article
- Uncaging carbon disulfide. Delivery platforms for potential pharmacological applications: a mechanistic approach.Chemical science · 2017Article
- LinkProt: a database collecting information about biological links.Nucleic acids research · 2017Article
- α-Carbonic Anhydrases Possess Thioesterase Activity.ACS medicinal chemistry letters · 2015Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extremophilic organisms require specialized enzymes for their exotic metabolisms. Acid-loving thermophilic Archaea that live in the mudpots of volcanic solfataras obtain their energy from reduced sulphur compounds such as hydrogen sulphide (H(2)S) and carbon disulphide (CS(2)). The oxidation of these compounds into sulphuric acid creates the extremely acidic environment that characterizes solfataras. The hyperthermophilic Acidianus strain A1-3, which was isolated from the fumarolic, ancient sauna building at the Solfatara volcano (Naples, Italy), was shown to rapidly convert CS(2) into H(2)S and carbon dioxide (CO(2)), but nothing has been known about the modes of action and the evolution of the enzyme(s) involved. Here we describe the structure, the proposed mechanism and evolution of a CS(2) hydrolase from Acidianus A1-3. The enzyme monomer displays a typical β-carbonic anhydrase fold and active site, yet CO(2) is not one of its substrates. Owing to large carboxy- and amino-terminal arms, an unusual hexadecameric catenane oligomer has evolved. This structure results in the blocking of the entrance to the active site that is found in canonical β-carbonic anhydrases and the formation of a single 15-Å-long, highly hydrophobic tunnel that functions as a specificity filter. The tunnel determines the enzyme's substrate specificity for CS(2), which is hydrophobic. The transposon sequences that surround the gene encoding this CS(2) hydrolase point to horizontal gene transfer as a mechanism for its acquisition during evolution. Our results show how the ancient β-carbonic anhydrase, which is central to global carbon metabolism, was transformed by divergent evolution into a crucial enzyme in CS(2) metabolism.
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