ArticleClinics (Sao Paulo, Brazil)2011
Simvastatin-induced cardiac autonomic control improvement in fructose-fed female rats.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Effect of Low Dose Atorvastatin Therapy on Baroreflex Sensitivity in Hypertensives.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2016Article
- Early developmental exposure to high fructose intake in rats with NaCl stimulation causes cardiac damage.European journal of nutrition · 2016Article
- Progressive Induction of Type 2 Diabetes: Effects of a Reality-Like Fructose Enriched Diet in Young Wistar Rats.PloS one · 2016Article
- Simvastatin and vitamin E effects on cardiac and hepatic oxidative stress in rats fed on high fat diet.Journal of physiology and biochemistry · 2013Article
- Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model.Cardiovascular diabetology · 2013Article
- Walking promotes metabolic and baroreflex sensitivity improvement in fructose-fed male rats.European journal of applied physiology · 2013Article
- Way back for fructose and liver metabolism: bench side to molecular insights.World journal of gastroenterology · 2012Review
- Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents.Clinics (Sao Paulo, Brazil) · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBecause autonomic dysfunction has been found to lead to cardiometabolic disorders and because studies have reported that simvastatin treatment has neuroprotective effects, the objective of the present study was to investigate the effects of simvastatin treatment on cardiovascular and autonomic changes in fructose-fed female rats.
methodsFemale Wistar rats were divided into three groups: controls (n = 8), fructose (n = 8), and fructose+ simvastatin (n = 8). Fructose overload was induced by supplementing the drinking water with fructose (100 mg/L, 18 wks). Simvastatin treatment (5 mg/kg/day for 2 wks) was performed by gavage. The arterial pressure was recorded using a data acquisition system. Autonomic control was evaluated by pharmacological blockade.
resultsFructose overload induced an increase in the fasting blood glucose and triglyceride levels and insulin resistance. The constant rate of glucose disappearance during the insulin intolerance test was reduced in the fructose group (3.4 ± 0.32%/min) relative to that in the control group (4.4 ± 0.29%/min). Fructose + simvastatin rats exhibited increased insulin sensitivity (5.4 ± 0.66%/min). The fructose and fructose + simvastatin groups demonstrated an increase in the mean arterial pressure compared with controls rats (fructose: 124 ± 2 mmHg and fructose+simvastatin: 126 ± 3 mmHg vs. controls: 112 ± 2 mmHg). The sympathetic effect was enhanced in the fructose group (73 ± 7 bpm) compared with that in the control (48 ± 7 bpm) and fructose+simvastatin groups (31 ± 8 bpm). The vagal effect was increased in fructose + simvastatin animals (84 ± 7 bpm) compared with that in control (49 ± 9 bpm) and fructose animals (46 ± 5 bpm).
conclusionSimvastatin treatment improved insulin sensitivity and cardiac autonomic control in an experimental model of metabolic syndrome in female rats. These effects were independent of the improvements in the classical plasma lipid profile and of reductions in arterial pressure. These results support the hypothesis that statins reduce the cardiometabolic risk in females with metabolic syndrome.
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