ReviewNature reviews. Neuroscience2011
Common cellular and molecular mechanisms in obesity and drug addiction.
Review in Nature reviews. Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 211 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
211 citing papers in PubMed, 7 syntheses or guidelines pooled it, 372 citations in OpenAlex.
- A meta-analysis assessing reliability of the Yale Food Addiction Scale: Implications for compulsive eating and obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- The impact of glucagon-like peptide-1 (GLP-1) agonists in the treatment of eating disorders: a systematic review and meta-analysis.Eating and weight disorders : EWD · 2025Pooled it
- Pooled it
- Can GLP-1 Be a Target for Reward System Related Disorders? A Qualitative Synthesis and Systematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol.Frontiers in behavioral neuroscience · 2020Pooled it
- Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis.International journal of obesity (2005) · 2018Pooled it
- Alcohol and Drug Use Among Postoperative Bariatric Patients: A Systematic Review of the Emerging Research and Its Implications.Alcoholism, clinical and experimental research · 2015Pooled it
- Childhood maltreatment and obesity: systematic review and meta-analysis.Molecular psychiatry · 2014Pooled it
- A randomized controlled experimental medicine study of ghrelin in value-based decision making.The Journal of clinical investigation · 2023Trial
- Behavioral activation for smoking cessation and the prevention of smoking cessation-related weight gain: A randomized trial.Drug and alcohol dependence · 2023Trial
- Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder.Drug and alcohol dependence · 2021Trial
- Frontostriatal and behavioral adaptations to daily sugar-sweetened beverage intake: a randomized controlled trial.The American journal of clinical nutrition · 2017Trial
- Effects of the opioid receptor antagonist naltrexone on smoking and related behaviors in smokers preparing to quit: a randomized controlled trial.Addiction (Abingdon, England) · 2013Trial
- Nicotine alters food-cue reactivity via networks extending from the hypothalamus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Naltrexone reduction of long-term smoking cessation weight gain in women but not men: a randomized controlled trial.Biological psychiatry · 2013Trial
- The claustrum encodes and scales appetitive feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Exploratory associations between co-occurring opioid and alcohol use disorders and GIP/GLP-1 receptor agonist treatment.Communications medicine · 2026Article
- Unhealthy food bias in food addiction: behavioral evidence from a probabilistic image choice task.Journal of eating disorders · 2026Article
- Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Motivation and reward processing across sex/gender and the menstrual cycle: a biopsychosocial perspective.Biology of sex differences · 2026Article
- The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events.Science advances · 2026Article
151 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hedonic properties of food can stimulate feeding behaviour even when energy requirements have been met, contributing to weight gain and obesity. Similarly, the hedonic effects of drugs of abuse can motivate their excessive intake, culminating in addiction. Common brain substrates regulate the hedonic properties of palatable food and addictive drugs, and recent reports suggest that excessive consumption of food or drugs of abuse induces similar neuroadaptive responses in brain reward circuitries. Here, we review evidence suggesting that obesity and drug addiction may share common molecular, cellular and systems-level mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.