ArticleMolecular autism2011
Investigation of the serum levels of anterior pituitary hormones in male children with autism.
Article in Molecular autism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Evaluation of thyroid function tests among children with neurological disorders.Frontiers in endocrinology · 2024Pooled it
- Alteration of peripheral cortisol and autism spectrum disorder: A meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Hyperandrogenism? Increased 17, 20-Lyase Activity? A Metanalysis and Systematic Review of Altered Androgens in Boys and Girls with Autism.International journal of molecular sciences · 2021Pooled it
- Concurrent Assessment of Neurotrophic Factors and HPA-Axis Hormones in Early Childhood Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Dysregulated HPA axis during postnatal developmental stages in the BTBR TNeuropsychopharmacology reports · 2025Article
- Feasibility, safety, and efficacy of high-dose intermittent theta burst stimulation in children with autism spectrum disorder: study protocol for a pilot randomized sham-controlled trial.Frontiers in psychiatry · 2025Article
- Article
- The GABA Polarity Shift and Bumetanide Treatment: Making Sense Requires Unbiased and Undogmatic Analysis.Cells · 2022Review
- A potential role for the adrenal gland in autism.Scientific reports · 2021Article
- Stress-induced alterations of social behavior are reversible by antagonism of steroid hormones in C57/BL6 mice.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Are Steroid Hormones Dysregulated in Autistic Girls?Diseases (Basel, Switzerland) · 2020Article
- A network of networks approach for modeling interconnected brain tissue-specific networks.Bioinformatics (Oxford, England) · 2019Article
- Steroid Metabolites Support Evidence of Autism as a Spectrum.Behavioral sciences (Basel, Switzerland) · 2019Article
- Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise.BioMed research international · 2017Article
- Altered ghrelin levels in boys with autism: a novel finding associated with hormonal dysregulation.Scientific reports · 2014Article
- Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders.Molecular autism · 2014Article
- Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome.Molecular autism · 2014Article
- GH Dysfunction in Engrailed-2 Knockout Mice, a Model for Autism Spectrum Disorders.Frontiers in pediatrics · 2014Article
- Altered metabolites in the plasma of autism spectrum disorder: a capillary electrophoresis time-of-flight mass spectroscopy study.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe neurobiological basis of autism remains poorly understood. The diagnosis of autism is based solely on behavioural characteristics because there are currently no reliable biological markers. To test whether the anterior pituitary hormones and cortisol could be useful as biological markers for autism, we assessed the basal serum levels of these hormones in subjects with autism and normal controls.
findingsUsing a suspension array system, we determined the serum levels of six anterior pituitary hormones, including adrenocorticotropic hormone and growth hormone, in 32 drug-naive subjects (aged 6 to 18 years, all boys) with autism, and 34 healthy controls matched for age and gender. We also determined cortisol levels in these subjects by enzyme-linked immunosorbent assay. Serum levels of adrenocorticotropic hormone, growth hormone and cortisol were significantly higher in subjects with autism than in controls. In addition, there was a significantly positive correlation between cortisol and adrenocorticotropic hormone levels in autism.
conclusionOur results suggest that increased basal serum levels of adrenocorticotropic hormone accompanied by increased cortisol and growth hormone may be useful biological markers for autism.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.