ArticleActa crystallographica. Section A, Foundations of crystallography2011
A multi-dataset data-collection strategy produces better diffraction data.
Article in Acta crystallographica. Section A, Foundations of crystallography, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
- Evolution of macromolecular crystallography beamlines at the Swiss Light Source and SwissFEL.Journal of synchrotron radiation · 2025Article
- Useful experimental aspects of small-wedge synchrotron crystallography for accurate structure analysis of protein molecules.Acta crystallographica. Section D, Structural biology · 2025Article
- Guidelines for de novo phasing using multiple small-wedge data collection.Journal of synchrotron radiation · 2021Article
- Long-wavelength Mesh&Collect native SAD phasing from microcrystals.Acta crystallographica. Section D, Structural biology · 2019Article
- Contemporary Use of Anomalous Diffraction in Biomolecular Structure Analysis.Methods in molecular biology (Clifton, N.J.) · 2017Review
- EIGER detector: application in macromolecular crystallography.Acta crystallographica. Section D, Structural biology · 2016Article
- Graphene-based microfluidics for serial crystallography.Lab on a chip · 2016Article
- Can I solve my structure by SAD phasing? Anomalous signal in SAD phasing.Acta crystallographica. Section D, Structural biology · 2016Article
- Assessing and maximizing data quality in macromolecular crystallography.Current opinion in structural biology · 2015Review
- Native SAD is maturing.IUCrJ · 2015Review
- Towards time-resolved serial crystallography in a microfluidic device.Acta crystallographica. Section F, Structural biology communications · 2015Article
- Fast native-SAD phasing for routine macromolecular structure determination.Nature methods · 2015Article
- Article
- Exploiting large non-isomorphous differences for phase determination of a G-segment invertase-DNA complex.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Robust structural analysis of native biological macromolecules from multi-crystal anomalous diffraction data.Acta crystallographica. Section D, Biological crystallography · 2013Article
- Squeezing the most from every crystal: the fine details of data collection.Acta crystallographica. Section D, Biological crystallography · 2013Article
- Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential.Journal of virology · 2013Article
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8 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
A multi-dataset (MDS) data-collection strategy is proposed and analyzed for macromolecular crystal diffraction data acquisition. The theoretical analysis indicated that the MDS strategy can reduce the standard deviation (background noise) of diffraction data compared with the commonly used single-dataset strategy for a fixed X-ray dose. In order to validate the hypothesis experimentally, a data-quality evaluation process, termed a readiness test of the X-ray data-collection system, was developed. The anomalous signals of sulfur atoms in zinc-free insulin crystals were used as the probe to differentiate the quality of data collected using different data-collection strategies. The data-collection results using home-laboratory-based rotating-anode X-ray and synchrotron X-ray systems indicate that the diffraction data collected with the MDS strategy contain more accurate anomalous signals from sulfur atoms than the data collected with a regular data-collection strategy. In addition, the MDS strategy offered more advantages with respect to radiation-damage-sensitive crystals and better usage of rotating-anode as well as synchrotron X-rays.
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