Evidence map›Paper›PMID 22011408›Full record

Trial reportDiabetes care2011

Safety and efficacy of 24-h closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes: a randomized crossover case series.

Helen R Murphy, Kavita Kumareswaran, Daniela Elleri, Janet M Allen, Karen Caldwell, Martina Biagioni, David Simmons, David B Dunger, Marianna Nodale, Malgorzata E Wilinska and 2 more

Erratum issuedOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 117 citations in OpenAlex.

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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Helen R MurphyMetabolic Research Laboratories and the National Institute for Health Research Cambridge Biomedical Research Center, University of Cambridge, Cambridge, UK. hm386@medschl.cam.ac.uk
Kavita Kumareswaran
Daniela Elleri
Janet M Allen
Karen Caldwell
Martina Biagioni
David Simmons
David B Dunger
Marianna Nodale
Malgorzata E Wilinska
Stephanie A Amiel
Roman Hovorka
National Institute for Health Research · GBUniversity of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GBSt Thomas' Hospital · GB

Funding

Department of Health PDF/01/036Diabetes UK 07/0003551Medical Research Council G0600717
6 · The paper itself

Abstract

objectiveTo evaluate the safety and efficacy of closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII). RESEARCH DESIGN AND

methodsA total of 12 women with type 1 diabetes (aged 32.9 years, diabetes duration 17.6 years, BMI 27.1 kg/m(2), and HbA(1c) 6.4%) were randomly allocated to closed-loop or conventional CSII. They performed normal daily activities (standardized meals, snacks, and exercise) for 24 h on two occasions at 19 and 23 weeks' gestation. Plasma glucose time in target (63-140 mg/dL) and time spent hypoglycemic were calculated.

resultsPlasma glucose time in target was comparable for closed-loop and conventional CSII (median [interquartile range]: 81 [59-87] vs. 81% [54-90]; P = 0.75). Less time was spent hypoglycemic (<45 mg/dL [0.0 vs. 0.3%]; P = 0.04), with a lower low blood glucose index (2.4 [0.9-3.5] vs. 3.3 [1.9-5.1]; P = 0.03), during closed-loop insulin delivery.

conclusionsClosed-loop insulin delivery was as effective as conventional CSII, with less time spent in extreme hypoglycemia.

Indexed as

Insulin Infusion SystemsAdultBlood GlucoseCross-Over StudiesDiabetes Mellitus, Type 1FemaleHumansHypoglycemiaInsulinPregnancyPregnancy in DiabeticsBlood GlucoseInsulin

Identifiers

PMID22011408
PMCPMC3220861
OpenAlexW2148062754

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.