SynthesisMalaria journal2011
Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis.
Synthesis in Malaria journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 6 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- ABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies.BMC medicine · 2024Pooled it
- Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis.The Journal of international medical research · 2022Pooled it
- ABO blood group and risk of malaria during pregnancy: a systematic review and meta-analysis.Epidemiology and infection · 2022Pooled it
- Effect of ABO blood group on asymptomatic, uncomplicated and placental Plasmodium falciparum infection: systematic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis.PloS one · 2013Pooled it
- Complement receptor 1 variants confer protection from severe malaria in Odisha, India.PloS one · 2012Pooled it
- A narrative review of the epidemiological and mechanistic associations between ABO blood groups and diseases: focusing on cardiovascular diseases, cancers, diabetes, malaria, COVID-19 and rheumatic diseases.Annals of medicine · 2026Review
- Beyond the mouse: organoids, spheroids, and organs-on-chips as the (inevitable) future of malaria research?Malaria journal · 2026Review
- Diabetes and metabolic syndrome in adults with malaria and associations with severe disease: results from two tertiary hospitals in Cameroon.BMC infectious diseases · 2025Article
- ABO and Rhesus blood group variability and their associations with clinical malaria presentations.Malaria journal · 2024Article
- ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies.iScience · 2023Review
- Immunochromatographic and microscopic detection of Plasmodium falciparum in recipients of P. falciparum-infected donor blood.Parasitology research · 2022Article
- Genotyping of ABO and Duffy blood groups among malaria patients in Thailand.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Article
- ABO Blood Group and the Risk of Esophageal Squamous Cell Carcinoma in Kashmir, a High Risk Region.Journal of gastrointestinal cancer · 2021Observational
- Prevalence and association of malaria with ABO blood group and hemoglobin level in individuals visiting Mekaneeyesus Primary Hospital, Estie District, northwest Ethiopia: a cross-sectional study.Parasitology research · 2021Article
- Are blood groups related to the distribution and severity of COVID-19? A cross-sectional study in a tertiary care hospital in South India.Qatar medical journal · 2021Article
- ABO blood group system is associated with COVID-19 mortality: An epidemiological investigation in the Indian population.Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine · 2020Article
- Asymptomatic carriage of Plasmodium falciparum by individuals with variant blood groups and haemoglobin genotypes in southern Ghana.Malaria journal · 2020Article
- TNF-α promoter polymorphisms (G-238A and G-308A) are associated with susceptibility to Systemic Lupus Erythematosus (SLE) and P. falciparum malaria: a study in malaria endemic area.Scientific reports · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundErythrocyte-associated antigenic polymorphisms or their absence have perhaps evolved in the human population to protect against malarial infection. Studies in various populations consistently demonstrate that blood group 'O' confers resistance against severe falciparum infection. In India, Odisha state has one of the highest incidences of Plasmodium falciparum infection and contributes to the highest number of deaths by falciparum malaria. This study aims to evaluate the relationship between ABO blood group and severe malaria in an adult population at the tertiary care centre in Odisha.
methodsA total of 353 P. falciparum infected subjects and 174 healthy controls were screened for ABO blood group. Falciparum-infected individuals were categorized as severe malaria and uncomplicated malaria. Severe malaria was further clinically phenotyped into cerebral malaria, non-cerebral severe malaria and multi-organ dysfunction. A meta-analysis was performed to assess the role of ABO blood group in severe malaria.
resultsFrequency of blood group 'B' was significantly higher in patients with severe malaria compared to the uncomplicated cases (P < 0.0001; OR = 4.09) and healthy controls (P < 0.0001; OR = 2.79). Irrespective of the level of clinical severity, blood group 'B' was significantly associated with cerebral malaria (P < 0.0001; OR = 5.95), multi-organ dysfunction (P < 0.0001; OR = 4.81) and non-cerebral severe malaria patients (P = 0.001; OR = 3.02) compared to the uncomplicated category. Prevalence of 'O' group in uncomplicated malaria (P < 0.0001; OR = 2.81) and healthy controls (P = 0.0003; OR = 2.16) was significantly high compared to severe malaria. Meta-analysis of previous studies, including the current one, highlighted the protective nature of blood group 'O' to severe malaria (P = 0.01). On the other hand, carriers of blood group 'A' (P = 0.04) and 'AB' (P = 0.04) were susceptible to malaria severity.
conclusionsResults of the current study indicate that blood group 'O' is associated with reduced and 'B' blood group with increased risk of development of severe malaria in Odisha, India. Meta-analysis also supports the protective nature of blood group 'O' from severe falciparum infection.
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