ArticleBMC evolutionary biology2011
A comparative assessment of mandible shape in a consomic strain panel of the house mouse (Mus musculus)--implications for epistasis and evolvability of quantitative traits.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Conserved but flexible modularity in the zebrafish skull: implications for craniofacial evolvability.Proceedings. Biological sciences · 2018Article
- Craniofacial shape transition across the house mouse hybrid zone: implications for the genetic architecture and evolution of between-species differences.Development genes and evolution · 2016Article
- Size and shape-integration of morphometrics, mathematical modelling, developmental and evolutionary biology.Development genes and evolution · 2016Article
- Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?G3 (Bethesda, Md.) · 2016Article
- Mapping of Craniofacial Traits in Outbred Mice Identifies Major Developmental Genes Involved in Shape Determination.PLoS genetics · 2015Article
- Contrasting genetic architectures in different mouse reference populations used for studying complex traits.Genome research · 2015Review
- Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.Frontiers in physiology · 2015Article
- The complex ontogenetic trajectory of mandibular shape in a laboratory mouse.Journal of anatomy · 2013Article
- Exploring the effects of gene dosage on mandible shape in mice as a model for studying the genetic basis of natural variation.Development genes and evolution · 2013Article
- Exploration of the genetic organization of morphological modularity on the mouse mandible using a set of interspecific recombinant congenic strains between C57BL/6 and mice of the Mus spretus species.G3 (Bethesda, Md.) · 2012Article
- Chromosome substitution strains: gene discovery, functional analysis, and systems studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- Modularity as a source of new morphological variation in the mandible of hybrid mice.BMC evolutionary biology · 2012Article
- Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice.BMC genetics · 2012Article
- Postnatal histomorphogenesis of the mandible in the house mouse.Journal of anatomy · 2012Article
- Micro-evolutionary divergence patterns of mandible shapes in wild house mouse (Mus musculus) populations.BMC evolutionary biology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExpectations of repeatedly finding associations between given genes and phenotypes have been borne out by studies of parallel evolution, especially for traits involving absence or presence of characters. However, it has rarely been asked whether the genetic basis of quantitative trait variation is conserved at the intra- or even at the interspecific level. This question is especially relevant for shape, where the high dimensionality of variation seems to require a highly complex genetic architecture involving many genes.
resultsWe analyse here the genetic effects of chromosome substitution strains carrying M. m. musculus chromosomes in a largely M. m. domesticus background on mandible shape and compare them to the results of previously published QTL mapping data between M. m. domesticus strains. We find that the distribution of genetic effects and effect sizes across the genome is consistent between the studies, while the specific shape changes associated with the chromosomes are different. We find also that the sum of the effects from the different M. m. musculus chromosomes is very different from the shape of the strain from which they were derived, as well as all known wild type shapes.
conclusionsOur results suggest that the relative chromosome-wide effect sizes are comparable between the long separated subspecies M. m. domesticus and M. m. musculus, hinting at a relative stability of genes involved in this complex trait. However, the absolute effect sizes and the effect directions may be allele-dependent, or are context dependent, i.e. epistatic interactions appear to play an important role in controlling shape.
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